Abstract:
Objective This study aims to investigate the expression of excision repair cross complementing 1(ERCCl) of hepatocellular carcinoma(HCC) and its clinical significance.
Methods The ERCC1 expression status of 226 patients with HCC, 65 with paraneoplastic tissue, and 17 with normal liver tissues was detected using immunohistochemistry.The correlation between ERCC 1 expression and major clinico-pathological characteristics and prognosis factors of HCC was analyzed.
Results The positive expression rate of ERCC1 in HCC was 44.2%(100 / 226), which was significantly higher compared with the paraneoplastic and non-cancer liver tissues(16.9% and 5.9%, respectively, all P < 0.05).The positive rate of ERCC1 in HCC cases with portal vein invasion was significantly higher compared with those without portal vein invasion(66.7%vs.42.3%, P < 0.05).Meanwhile, the expression of ERCC1 was not significantly associated with age and other clinical characteristics(P > 0.05, respectively).In the HCC group treated with radical resection(184 patients), the positive rate of ERCC 1 noticeably decreased when the median time to recurrence or metastasis(TTR /M) became longer.The group with positive expression of ERCC1 exhibited a shorter TTR/M compared with the group with negative expression(10.3 m vs.20.3 m, P < 0.05).The Cox regression model analysis showed that the preoperative serum levels of aspartate amionotransferase≥2.5 N, tumor size > 5 cm, and the positive expression of ERCC1 were the independent risk factors of recurrence or metastasis of HCC.
Conclusion ERCC1 expression was obviously higher in HCC than in the paraneoplastic and normal liver tissues, respectively.The overexpression of ERCC1 was significantly correlated with the portal vein invasion and the risk of recurrence or metastasis of HCC after radical resection.
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