Abstract:
Objective Medulloblastoma is one of the most common malignant tumors of the posterior cranial fossa in children. Our study investigated the expression ofNrf-2 (nuclear factor erythroid2-related factor2) and HO-1 (heme oxygenase-I) using immunohistochemistry. The cells of medulloblastoma were compared with cells in the normal brain tissue adjacent to the tumor to explore their role and significance in medulloblastoma.
Methods 41 one cases of medulloblastoma and 27 control cases of peritumoral normal brain tissue were analyzed together with their clinical data (gender, age, clinical symptoms, tumor size, and tumor pathological type). The expressions of Nrf-2 and HO-1 protein were detected by immunohistochemical staining. Their correlation and relationship with clinical manifestations were analyzed as well.
ResuLts In the cases of medulloblastoma, Nrf-2 and HO-1 positive expression rates (82.9% and 78.0%, respectively) significantly increased compared with the positive expression rate of peritumoral normal brain cells (37.0% and 29.6%, respectively). The difference was statistically significant (P < 0.001). A positive correlation between the expressions of Nrf-2 and HO-1 in medulloblastoma (rs= 0.542, P < 0.05) was observed. However, no definite correlation was found among the expressions ofNrf-2, HO-1, and the clinical pathological features (P > 0.05).
Conclusion The abnormal expressions of Nrf-2 and HO-1 in medulloblastoma suggest that the Nrf-2/HO-1 pathway plays an important role in the formation and development of medulloblastoma.
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