JEB方案治疗22例儿童卵黄囊瘤的临床疗效分析

何珂骏; 袁晓军; 张勤; 盛琦

doi:10.3969/j.issn.1000-8179.2012.15.012

JEB方案治疗22例儿童卵黄囊瘤的临床疗效分析

Efficacy of Protocol JEB in 22 Children with Yolk Sac Tumors

摘要

摘要:
目的探讨JEB化疗方案对儿童卵黄囊瘤的临床疗效。
方法 2007年3月至2011年12月上海交通大学医学院附属新华医院收治的22例行JEB方案化疗的卵黄囊瘤患儿, 分析年龄、性别、原发部位、Brodeur分期、肿瘤大小等因素对预后的影响。
结果在22例卵黄囊瘤患儿中, 初发病例18例, 复发4例; 男性8例, 女性14例, 中位发病年龄为21.5(6~132)个月。4年总体生存(OS)率为(79.9±17.8)%, 无事件生存(EFS)率(69.3±20.8)%。复发患儿再次缓解率达100%。
结论以JEB方案结合手术切除肿瘤能明显改善卵黄囊瘤患儿的预后, 尤其对复发患儿有一定疗效。

Abstract:
Objective To investigate the clinical efficacy of protocol JEB in 22 children with yolk sac tumors.
Methods From March 2007 to December 20ll, 22 child patients with yolk sac tumor were enrolled in the protocol JEB group. Prognosis related with the age, sex, Brodeur stage, tumor size, and primary patient site was analyzed.
Results Among 22 patients with yolk sac tumor, 18 were newly diagnosed and 4 relapsed after primary treatment. The group was composed of 8 males and 14 females. The median age was 21.5 (6 to 132) months. The four-year overall survival (OS) and event-free survival (EFS) rates were 79, 9±17.8% and 69.31 20.8%, respectively. Children who relapsed had a 100% response rate to the protocol.
Conclusion The combination of protocol JEB and surgical resection can improve survival and have a certain effect on relapsed patients.

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