Abstract:
Objective To investigate the clinical efficacy of protocol JEB in 22 children with yolk sac tumors.
Methods From March 2007 to December 20ll, 22 child patients with yolk sac tumor were enrolled in the protocol JEB group. Prognosis related with the age, sex, Brodeur stage, tumor size, and primary patient site was analyzed.
Results Among 22 patients with yolk sac tumor, 18 were newly diagnosed and 4 relapsed after primary treatment. The group was composed of 8 males and 14 females. The median age was 21.5 (6 to 132) months. The four-year overall survival (OS) and event-free survival (EFS) rates were 79, 9±17.8% and 69.31 20.8%, respectively. Children who relapsed had a 100% response rate to the protocol.
Conclusion The combination of protocol JEB and surgical resection can improve survival and have a certain effect on relapsed patients.