冯莉霞, 王华庆, 贺瑾. 延胡索合剂预防和治疗肿瘤化疗性静脉炎的实验研究[J]. 中国肿瘤临床, 2012, 39(15): 1073-1076. DOI: 10.3969/j.issn.1000-8179.2012.15.020
引用本文: 冯莉霞, 王华庆, 贺瑾. 延胡索合剂预防和治疗肿瘤化疗性静脉炎的实验研究[J]. 中国肿瘤临床, 2012, 39(15): 1073-1076. DOI: 10.3969/j.issn.1000-8179.2012.15.020
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Li xia FENG, Hua qing WANG, Jin HE. Efficacy of Chinese Medicine(Jing Yan An) for Prevention and Treatment of Chemotherapy-induced Phlebitis[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(15): 1073-1076. DOI: 10.3969/j.issn.1000-8179.2012.15.020
Citation: Li xia FENG, Hua qing WANG, Jin HE. Efficacy of Chinese Medicine(Jing Yan An) for Prevention and Treatment of Chemotherapy-induced Phlebitis[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(15): 1073-1076. DOI: 10.3969/j.issn.1000-8179.2012.15.020
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延胡索合剂预防和治疗肿瘤化疗性静脉炎的实验研究

Efficacy of Chinese Medicine(Jing Yan An) for Prevention and Treatment of Chemotherapy-induced Phlebitis

    摘要
  • 摘要:
      目的  以延胡索、大黄、侧柏叶、蒲黄等几味中草药为主要组方的"静炎安", 用于化疗药物外渗性损伤及化疗性静脉炎的外敷, 本研究旨在观察静炎安对兔耳缘静脉化疗性静脉炎的防护机制。
      方法  选取24只大白兔, 建立兔耳缘模型, 并分为静炎安组、硫酸镁组、空白对照组, 分别采取静炎安湿敷、硫酸镁湿敷、无任何干预措施。观察静脉炎发生情况, 并于干预后48h、7d取局部静脉及周围组织切片行HE染色, 观察病理损伤程度及愈合情况; 行血管内皮生长因子(vascular endothelial growth factor, VEGF)、细胞间黏附分子(intercellular adhesion molecule-1, ICAM-1)免疫组织化学法染色, 观察VEGF、ICAM-1表达情况。
      结果  静炎安组较硫酸镁组及空白对照组静脉炎损伤程度轻, 愈合早, VEGF、ICAM-1表达下调。
      结论  静炎安通过促进血管内皮细胞增生和修复, 减轻炎症反应, 进而对化疗性静脉炎有良好的防护作用。

     

    Abstract:
      Objective  To observe the protective effects of Jing Yan An, a Chinese medical compound mixed with a few herbs such as Corydalis turber, rhubarb, Biota orientalis, and Pollen Typhae, on pirarubicin-induced venous injury of the rabbit ear vein.
      Methods  A total of 24 rabbits were used to model the pirarubicin-induced venous injury. The models were divided into the Jing Yan An group, the magnesium sulfate group, and the blank control group. The groups were provided with hydropathic compression of Jing Yah An, magnesium sulfate, and normal saline, respectively. The occurrence of phlebitis was observed. Local vein and peripheral tissue histopathologic slides and HE staining were carried out at 48 hours and 7 days after intervention, respectively. Pathologic damage and healing state of the vein and peripheral tissue were observed. Vascular endothelial growth factor (VEGF) and intercellular adhesion molecule-1 (ICAM-1) expressions in the vein and in the peripheral tissue were detected by immunohistochemistry.
      Results  Compared with the magnesium sulfate and blartk control groups, the Jing Yah An group exhibited milder phlebitis, earlier healing, and higher VEGF and ICAM-1 expressions.
      Conclusion  Jing Yan An exhibited good effect on preventing and treating chemotherapy-induced phlebitis.

     

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