乳腺癌相关性视网膜病变研究进展

Progress in the Study of Breast Cancer-associated Retinopathy

摘要: 乳腺癌相关性视网膜病变(breast cancer-associated retinopathy, BCAR)是一种较为罕见的疾病, 需要与肿瘤转移所致的视网膜病变相区别, BCAR在乳腺癌患者中的发病率较低。有关BCAR的定义、临床表现、治疗等均无统一定论, 当部分乳腺癌患者诊治过程中出现眼部症状时往往将其归为化疗副作用, 或误诊为糖尿病视网膜病变、老年性白内障等, 而未考虑到BCAR。早期诊治将有助于提高BCAR患者的生存质量, 本文综述了BCAR的发病机制、发病率、临床表现及诊断、治疗和预后。

Abstract: Breast cancer-associated retinopathy (BCAR) is a paraneoplastic neurologic syndrome that results in progressive loss of vision and retinal degeneration. The morbidity rate of cancer-associated retinopathy among breast cancer patients is reportedly 0.68%. However, to date, few studies have focused on BCAR. The ocular symptoms of breast cancer are often misdiagnosed by some physicians as side effects of drugs, diabetic retinopathy, or senile cataract. Early diagnosis and treatment of BCAR improve the quality of life of patients. This article reviews the etiology, pathogenesis, morbidity, clinical manifestations, diagnosis, treatment, and prognosis of BCAR.