Abstract:
Platelet-denved growth factor (PDGF) is a pro angtogemc ia PDGFR) is a family member of the tyrosine protein kinase receptors, which can 1 hemotaxis, cleavage, and proliferation. PDGFR also plays an important role in growth and development, wound repair, as well as other physiological processes. As angiogenesis factors, PDGF and PDGFR play critical roles in tumorigenesis, tumor progression, and metastasis. PDGF released by tumor cells can induce the proliferation and migration of vascular endothelial ceils, smooth muscle cells, and tumor cells, in addition to their apoptosis. Indeed, significant progress has been achieved in targeted therapy for cancer based on PDGF/PDGFR. This article reviews the research developments in the role of PDGF/PDGFR in the process of tumor and targeted therapy.