甄海宁, 河井信行, 冈田真树, 大久保修一, 田宫隆, 章翔, 刘卫平, 霍军丽, 费舟. 4F2hc表达与人脑胶质瘤病理级别增殖和血管形成的关系[J]. 中国肿瘤临床, 2012, 39(16): 1161-1164. DOI: 10.3969/j.issn.1000-8179.2012.16.007
引用本文: 甄海宁, 河井信行, 冈田真树, 大久保修一, 田宫隆, 章翔, 刘卫平, 霍军丽, 费舟. 4F2hc表达与人脑胶质瘤病理级别增殖和血管形成的关系[J]. 中国肿瘤临床, 2012, 39(16): 1161-1164. DOI: 10.3969/j.issn.1000-8179.2012.16.007
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Haining ZHEN, Nobuyuki KAWAI, Masaki OKADA, Shuichi OKUBO, Takashi TAMIYA, Xiang ZHANG, Weiping LIU, Junli HUO, Zhou FEI. Relation of 4F2hc Expression to Pathological Grade Proliferation and Angiogenesis in Human Brain Gliomas[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(16): 1161-1164. DOI: 10.3969/j.issn.1000-8179.2012.16.007
Citation: Haining ZHEN, Nobuyuki KAWAI, Masaki OKADA, Shuichi OKUBO, Takashi TAMIYA, Xiang ZHANG, Weiping LIU, Junli HUO, Zhou FEI. Relation of 4F2hc Expression to Pathological Grade Proliferation and Angiogenesis in Human Brain Gliomas[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(16): 1161-1164. DOI: 10.3969/j.issn.1000-8179.2012.16.007
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4F2hc表达与人脑胶质瘤病理级别增殖和血管形成的关系

Relation of 4F2hc Expression to Pathological Grade Proliferation and Angiogenesis in Human Brain Gliomas

    摘要
  • 摘要:
      目的  探讨细胞表面抗原4F2重链(4F2 heavy chain, 4F2hc)在人脑胶质瘤组织中的表达水平及其与胶质瘤病理学特征、细胞增殖以及血管形成的关系。
      方法  采用免疫组化方法检测4F2hc、Ki-67和CD34在62例人脑胶质瘤组织中的表达, 计数Ki-67标记指数(Ki-67 LI)和微血管密度(MVD)。
      结果  4F2hc在胶质瘤中高表达, 其免疫阳性染色既定位于瘤细胞也定位于血管内皮; 4F2hc表达随胶质瘤病理级别升高而明显增强(P=0.001), 在高度恶性胶质瘤中4F2hc表达明显强于低度恶性胶质瘤(P=0.002);4F2hc表达与胶质瘤Ki-67标记指数存在明显正相关(P=0.003), 但与微血管密度无明显相关性(P=0.214)。
      结论  4F2hc与胶质瘤的发生和发展关系密切, 可能在胶质瘤的恶性增殖过程中具有重要作用。

     

    Abstract:
      Objective  To investigate the expression level of the cell surface antigen 4F2 heavy chain (4F2hc) and its relation to pathological features, cell proliferation, and angiogenesis in human brain gliomas.
      Methods  The expressions of 4F2hc, Ki-67, and CD34 were examined through immunohistochemistry. Ki-67 labeling index (Ki 67 LI) and microvessel density (MVD) were also measured in 62 cases of human brain glioma.
      Results  4F2hc was over-expressed in the glioma tissues. Its immunoreactivity was found in the tumor cells and in the vascular endothelia. The expression of 4F2hc was significantly enhanced as the glioma pathological grade increased (P= 0.001), which was significantly higher in the malignant glioma tissues than in the benign glioma tissues (P= 0.002). 4F2hc expression was markedly and positively correlated with Ki-67 labeling index (P= 0.003). However, no significant correlation was observed with microvessel density (P= 0.214).
      Conclusions  4F2hc is closely associated with the formation and progression of gliomas, and may play an important role in the latter's malignant proliferation.

     

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