Abstract:
Objectives The aim of the current paper was to evaluate the role of the NF-kB and CXCR4 expressions in the oncogenesis, development, infiltration, and metastasis of colorectal adeno-carcinoma (CAdCa) and their clinical significances.
Methods The expression of NF-KB and CXCR4 in 60 cases with CAdCa, 23 with canalicular adenoma of large intestine (CALl), and 25 with normal colorectal mucosa (NCM) were detected using the SP irnmuno-histochemical method.
Results The positive expression of NF-KB and CXCR4 were both higher in the CAdCa group compared with the CALl and NCM groups (P < 0.05). This positive expression was higher in the CALl group than in the CNM group. Statistically significant differences have been observed among the expressions in the CAdCa, CALl, and NCM groups (P < 0.05). However, stronger expression of NF-kB and CXCR4 protein was observed in CAdCa, compared with that in normal paraneoplastic tissues (P < 0.05). The positive expression of NF-KB and CXCR4 was closely correlated with the depth of tumor infiltration and the nodal metastasis (P < 0.05). Moreover, a positive correlation was also observed between the expression of NF-KB and CXCR4 in CAdCa (r= 0.346, P= 0.007).
Conclusion The over-expression of NF-KB and CXCR4 are closely correlated with the infiltration and metastasis of CAdCa.