OVA66在胃癌中的表达及临床意义

黄宝俊; 杨帆; 赵雨杰; 李腾; 徐惠绵

doi:10.3969/j.issn.1000-8179.2012.16.011

OVA66在胃癌中的表达及临床意义

Expression and Clinical Significance of OVA66 in Gastric Cancer

摘要

摘要:
目的研究OVA66在胃癌中的表达情况, 及其与胃癌侵袭、转移和预后的相关性。
方法以52例胃癌患者为研究对象, 分别运用RT-PCR、免疫组化方法检测OVA66在胃原发癌、癌旁正常胃黏膜、淋巴结转移癌中的表达, 对所有病例进行随访, 分析OVA66与胃癌侵袭、转移和预后的相关性。
结果 OVA66在胃原发癌和淋巴结转移癌中表达明显增高, 而在癌旁正常胃黏膜中几乎不表达, 差异具有显著性(P < 0.05)。OVA66表达在浸润型癌、癌侵透浆膜、浆膜受侵面积 < 20 cm^2、淋巴结分期晚者中明显增高(P < 0.01)。OVA66高表达组患者5年生存率为27.5%, 而OVA66低表达组为58.3%, 差异有统计学意义(χ²=10.10, P=0.0015)。
结论 OVA66基因表达与胃癌的侵袭、转移和预后有关, 是反映胃癌恶性生物学行为较好的分子指标。

Abstract:
Objective This study investigates the expression of OVA66 in gastric cancer and evaluates the correlation between expression and invasion and between metastasis and prognosis.
Methods A total of 52 patients with gastric cancer were selected and followed up. The expression of OVA66 in the primary focus of the stomach, normal gastric mucosa, and metastatic lymph node were examined by reverse transcription-polymerase chain reaction (RT PCR) and immunohistochemistry, respectively. The correlations between the OVA66 expression and tumor invasion, metastasis, and prognosis, were assessed.
Results The expression of OVA66 in gastric primary focus and metastatic lymph nodes significantly increased, but was nearly absent in the normal gastric mucosa (P < 0.05). The expression of OVA66 was significantly higher in patients with infiltrating-type gastric cancer, penetrated serosa, areas of serosa over 20 cm², and metastatic nodes over 7 (P < 0.01). The patients with a higher OVA66 expression (27.5 %) had a significantly lower survival rate compared with that of patients with lower OVA66 expression (58.3 %), χ² = 10.10, P= 0.001 5).
Conclusion The up-regulated expression of OVA66 has a major fimction in tumor invasion, metastasis, and poor prognosis. The expression of OVA66 is a good molecular marker that reflects the biological behaviors of gastric cancer.

HTML全文

参考文献(10)

施引文献

资源附件(0)