程艳, 姚丽, 崔金全. TS和PCNA与子宫内膜癌的相关性研究[J]. 中国肿瘤临床, 2012, 39(16): 1192-1195. DOI: 10.3969/j.issn.1000-8179.2012.16.015
引用本文: 程艳, 姚丽, 崔金全. TS和PCNA与子宫内膜癌的相关性研究[J]. 中国肿瘤临床, 2012, 39(16): 1192-1195. DOI: 10.3969/j.issn.1000-8179.2012.16.015
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Yan CHENG, Li YAO, Jinquan CUI. Expression of Thymidylate Synthase and Proliferative Cell Nucleax Antigen and their Relationship with Endometrial Carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(16): 1192-1195. DOI: 10.3969/j.issn.1000-8179.2012.16.015
Citation: Yan CHENG, Li YAO, Jinquan CUI. Expression of Thymidylate Synthase and Proliferative Cell Nucleax Antigen and their Relationship with Endometrial Carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(16): 1192-1195. DOI: 10.3969/j.issn.1000-8179.2012.16.015
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TS和PCNA与子宫内膜癌的相关性研究

Expression of Thymidylate Synthase and Proliferative Cell Nucleax Antigen and their Relationship with Endometrial Carcinoma

    摘要
  • 摘要:
      目的  检测子宫内膜癌中胸苷酸合成酶(TS)和细胞增殖核抗原(PCNA)的表达情况, 探讨其与子宫内膜癌预后的关系及临床意义。
      方法  用免疫组化S-P法检测15例正常子宫内膜、10例子宫不典型增生、48例子宫内膜癌石蜡标本中的TS和PCNA蛋白表达情况。
      结果  采用免疫染色强度与阳性细胞率法判断免疫组化结果, TS蛋白在子宫内膜癌与正常内膜中的表达有显著性差异(P=0.008), TS表达与肿瘤低分化(P=0.021)、深层浸润(P=0.010)、手术病理分期晚期(P=0.047)、淋巴结转移(P=0.022)密切相关; 子宫内膜癌中PCNA表达显著高于正常内膜(P < 0.01)。PCNA在子宫内膜癌组织中表达高于非典型增生子宫内膜, 差异有统计学意义(P=0.002)。PCNA表达程度与分化程度(P=0.010)、肌层浸润(P=0.001)有关。TS和PCNA的表达呈正相关(r=0.71, P < 0.01)。
      结论  TS和PCNA在子宫内膜癌组织中的表达增加, 其表达水平与子宫内膜癌病变程度呈正相关, 可能与子宫内膜癌预后有关

     

    Abstract:
      Objective  To study the expression of thymidylate synthase and proliferative cell nucleax antigen in endometrial carcinoma and their relationship with the prognosis.
      Methods  Expression of two indexes was detected by immunohistochemistry in 48 endometrial carcinoma tissues. Their relationship with the clinicopathological parameters and prognosis was analyzed.
      Results  TS expression in EMC significantly increased compared with that in the normal group (P= 0.008). TS expression was significantly correlated with four clinicopathologic parameters: histologic type (P= 0.021), depth of invasion (P= 0.010), clinical stage (P= 0.047), and lymph node metastasis (P= 0.022) PCNA expression in EMC significantly increased compared with that in the normal group (PPC NA = 0.000) and in the atypical hyperplasia group (P= 0.002). PCNA expression correlated with the differentiation (P= 0.010) and myometrial invasion (P= 0.001). TS expression was positively correlated with PCNA (r= 0.71, P < 0.01).
      Conclusion  TS and PCNA expressions in EMC significantly increased, indicating their possible importance as prognostic indicators of endometrial carcinoma.

     

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