刘星, 黎乐群, 向邦德, 马良, 钟鉴宏, 游雪梅. 巴塞罗那肝癌临床分期B期肝细胞性肝癌手术与TACE疗效比较[J]. 中国肿瘤临床, 2012, 39(16): 1225-1228. DOI: 10.3969/j.issn.1000-8179.2012.16.023
引用本文: 刘星, 黎乐群, 向邦德, 马良, 钟鉴宏, 游雪梅. 巴塞罗那肝癌临床分期B期肝细胞性肝癌手术与TACE疗效比较[J]. 中国肿瘤临床, 2012, 39(16): 1225-1228. DOI: 10.3969/j.issn.1000-8179.2012.16.023
shu
Xing LIU, Lequn LI, Bangde XIANG, Liang MA, Jianhong ZHONG, Xuemei YOU. Efficacy of Hepatic Resection and Transarterial Chemoembolization for Stage B Hepatocellular Carcinoma in the Barcelona Clinic Liver Cancer Classification[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(16): 1225-1228. DOI: 10.3969/j.issn.1000-8179.2012.16.023
Citation: Xing LIU, Lequn LI, Bangde XIANG, Liang MA, Jianhong ZHONG, Xuemei YOU. Efficacy of Hepatic Resection and Transarterial Chemoembolization for Stage B Hepatocellular Carcinoma in the Barcelona Clinic Liver Cancer Classification[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(16): 1225-1228. DOI: 10.3969/j.issn.1000-8179.2012.16.023
shu

巴塞罗那肝癌临床分期B期肝细胞性肝癌手术与TACE疗效比较

Efficacy of Hepatic Resection and Transarterial Chemoembolization for Stage B Hepatocellular Carcinoma in the Barcelona Clinic Liver Cancer Classification

    摘要
  • 摘要:
      目的  比较肝细胞性肝癌(HCC)巴塞罗那肝癌临床(BCLC)分期B期患者行肝切除术及经肝动脉化疗栓塞(TACE)治疗的疗效。
      方法  回顾性分析2003年1月至2006年8月共222例BCLC B期、Child-PughA级HCC患者的生存资料, 采用t检验及秩和检验进行组间比较, 采用Cox模型分析危险因素, Kaplan-Meier曲线法分析总生存率。
      结果  222例患者中, 肝切除术治疗118例, TACE治疗104例。肝切除术组患者的1、3、5年总生存率分别为76%、46%、37%, 中位生存期为29个月; TACE组患者的总生存率分别为53%、19%、7%, 中位生存期为11个月(P < 0.05)。Cox回归模型提示治疗方式TACE是影响预后的危险因素。
      结论  肝切除术较TACE治疗可能更能提高BCLC B期、Child-Pugh A级HCC患者的总生存率。BCLC B期HCC的治疗方式应该按不同的亚组行更为细致的划分。

     

    Abstract:
      Objective  The objective of this study was to compare the efficacy of hepatic resection and transarterial chemoembolization (TACE) for patients with stage B hepatocellular carcinoma (HCC) in the Barcelona Clinic Liver Cancer (BCLC) classification.
      Methods  Clinical data of 222 patients diagnosed with BCLC stage B liver cancer and Child Pugh A HCC between January 2003 and August 2006 were included in this retrospective study. Different statistical methods were used to compare the survival rates of the two groups. Risk factors were analyzed using the Cox regression model, whereas overall survival rates were analyzed using Kaplan Meier curves.
      Results  Of the 222 patients, 118 underwent hepatic resection and 104 received TACE. The 1-, 3-, and 5-year overall survival rates for the hepatic resection group were 76 %, 46 %, and 37 %, respectively, whereas those for the TACE group were 53 %, 19 %, and 7 %, respectively. The median survival times were 29 and 11 months for the hepatic resection group and TACE group, respectively (P < 0.05). Cox regression model analysis showed that TACE was the risk factor affecting prognosis.
      Conclusions  Hepatic resection for patients with BCLC stage B liver cancer and Child Pugh A HCC might have better survival rates compared with TACE. Different treatment strategies should be conducted in patients of different subgroups with BCLC stage B HCC.

     

    • HTML全文
    • 参考文献(13)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回