Abstract:
Objective To aimed to analyze the infection status of female patients with Kaposi's sarcoma-associated herpesvirus (KSHV) and its relationship with the occurrence of cervical lesions.
Methods For the study group, 440 histological cases with confirmed cervical intraepithelial neoplasia (CIN) and cervical squamous cell cancer (SCC) were randomly selected. Simultaneously, 380 cases without cervical lesions in the same region were physically examined as the control group. Blood and cervical cell samples were collected for DNA extraction, and the KSHV ORF26 was detected using nested PCR and gel electrophoresis.
Results The KSHV detection rate of blood samples in the study group was 12.9% (53/412), whereas that in the control group was 6.5% (23/354). The difference between the two groups was statistically significant (P < 0.01), but KSHV could not be detected in the cervical cell samples. Stratified analysis was applied for the study group, and the detection rate of KSHV was found to significantly increase with the aggravation of cervical lesions and with increasing age (P < 0.05).
Conclusion The KSHV detection rate in females with cervical lesions is higher than in normal females. Thus, KSHV can potentially strengthen the monitoring of cervical lesions.