漫彦文, 刘剑勇, 赵荫农, 张志明, 袁卫平, 向邦德, 吴飞翔. 53例肝细胞癌患者根治性切除术后辅助肝动脉化疗栓塞的生存分析[J]. 中国肿瘤临床, 2012, 39(17): 1321-1324. DOI: 10.3969/j.issn.1000-8179.2012.17.014
引用本文: 漫彦文, 刘剑勇, 赵荫农, 张志明, 袁卫平, 向邦德, 吴飞翔. 53例肝细胞癌患者根治性切除术后辅助肝动脉化疗栓塞的生存分析[J]. 中国肿瘤临床, 2012, 39(17): 1321-1324. DOI: 10.3969/j.issn.1000-8179.2012.17.014
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Yanwen MAN, Jianyong LIU, Yinnong ZHAO, Zhiming ZHANG, Weiping YUAN, Bangde XIANG, Feixiang WU. Survival Analysis of 53 Patients with Hepatocellular Carcinoma Undergoing Adjuvant Transcatheter Arterial Chemoembolization after Radical Resection[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(17): 1321-1324. DOI: 10.3969/j.issn.1000-8179.2012.17.014
Citation: Yanwen MAN, Jianyong LIU, Yinnong ZHAO, Zhiming ZHANG, Weiping YUAN, Bangde XIANG, Feixiang WU. Survival Analysis of 53 Patients with Hepatocellular Carcinoma Undergoing Adjuvant Transcatheter Arterial Chemoembolization after Radical Resection[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(17): 1321-1324. DOI: 10.3969/j.issn.1000-8179.2012.17.014
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53例肝细胞癌患者根治性切除术后辅助肝动脉化疗栓塞的生存分析

Survival Analysis of 53 Patients with Hepatocellular Carcinoma Undergoing Adjuvant Transcatheter Arterial Chemoembolization after Radical Resection

    摘要
  • 摘要:
      目的   探讨肝细胞癌根治性切除术后辅助肝动脉化疗栓塞对无瘤生存率及累积生存率的影响。
      方法   收集53例肝细胞癌根治性切除术后辅助TACE治疗患者和64例单纯行肝细胞癌根治术后患者的临床资料，采用回顾性研究的方法，对其治疗的1、2、3、5无瘤生存率和累积生存率进行对比分析，从而探讨肝细胞癌根治性切除术后辅助TACE治疗对无瘤生存率及累积生存率的影响。
      结果   术后+TACE组1、2、3、5年的无瘤生存率和累积生存率分别为84.9%、60.4%、39.6%、18.9%和98.1%、86.8%、69.8%、47.2%，单纯手术组1、2、3、5年的无瘤生存率和累积生存率分别为70.3%、43.8%、21.9%、12.5%和87.5%、71.9%、50.0%、31.3%，两组的无瘤生存率和累积生存率差异均有统计学意义。Cox回归结果显示术后+TACE治疗是影响患者无瘤生存率和累积生存率的独立影响因素。
      结论   肝细胞癌根治性切除术后辅助TACE治疗可提高患者的无瘤生存率和累积生存率，术后辅助TACE治疗是影响患者术后无瘤生存率和累积生存率的独立影响因素。

     

    Abstract:
      Objective   This study investigates the effect of adjuvant trans-catheter arterial chemo-embolization (TACE) treatment after radical resectioning of the hepato-cellular carcinoma (HCC) on disease-free and accumulative survivals.
      Methods   The clinical data of 53 HCC patients who underwent postoperative adjuvant TACE treatment and 64 patients undergoing simple surgery of HCC were collected. The 1-, 2-, 3-, and 5-year disease-free and accumulative survival rates of the patients were retrospectively studied to analyze the effect of auxiliary TACE treatment on disease-free and accumulative survival rates after HCC surgery.
      Results   The 1-, 2-, 3-, and 5-year disease-free and accumulative survival rates in the group with TACE treatment after resection were 84.9%, 60.4%, 39.6%, and 18.9%, and 98.1%, 86.8%, 69.8%, and 47.2% respectively. The disease-free and accumulative survival rates of the group with simple HCC surgery were 70.3%, 43.8%, 21.9%, and 12.5%, and 87.5%, 71.9%, 50.0%, and 31.3%, respectively. The log-rank test for the two groups were statistically different between the two cases. The COX regression equation results showed that the treatment with radical surgery plus adjuvant TACE is an independent factor that affects the disease-free and accumulate survival rates.
      Conclusion   TACE treatment after HCC radical surgery is an independent factor that can improve the disease-free and accumulative survival rates of the patients.

     

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