Abstract:
Objective This study aims to investigate the expression of the kallikrein 10 (KLK10) gene and the trefoil factor family-3 (TFF3) in colorectal carcinoma, and explore their possible relationships and clinicopathological characteristics.
Methods KLK10 and TFF3 expressions were detected by immunohistochemical staining (SP) in tissues from 57 patients with colorectal carcinoma, 21 cases of colorectal adenoma, and 11 cases of normal colorectal mucosa.
Results The positive expression rates of KLK10 and TFF3 in colorectal carcinoma were 66.7 % (38 / 57) and 70.2 % (40 / 57), respectively; whereas 38.1 % (8 / 21) and 47.6 % (10 / 21) in colorectal adenoma, and 27.3 % (3 / 11) and 90.9 % (10 / 11) in normal colorectal mucosa, respectively. Statistical analysis indicated that the KLK10 and TFF3 positive expression rates in colorectal carcinoma differed significantly from that in colorectal adenoma and normal colorectal mucosa (P < 0.05). KLK10 and TFF3 expressions were significantly correlated with lymphatic invasion and TNM staging (P < 0.05). A high positive correlation was observed between the KLK10 and TFF3 expression in colorectal carcinoma (r =0.597, P < 0.001).
Conclusion KLK10 and TFF3 expression are related to the lymphatic invasion and TNM stage of colorectal carcinoma. Therefore providing information for further diagnosis and therapy to patients is helpful.