Abstract:
Objective To evaluate the therapeutic effects and adverse reactions of patients with oral squamous cell carcinoma (OSCC) to continuous intra-arterial infusion chemotherapy via the superficial temporal artery.
Methods Atotal of 53 patients with OSCC underwent intra-arterial chemotherapy. Treatment consisted of selective intra-arterial infusions. The histologic tumor regression grades of OSCC as well as the therapeutic effects and adverse reactions of the treatment were evaluated.
Results After the first, second, and third sessions of continuous intra-arterial infusion chemotherapy, 58.49 %, 76.60 %, and 84.62 % complete responses on the primary site were achieved, respectively. The corresponding values for grades Ⅲor Ⅳ histologic tumor regression were 33.33 %, 61.90 %, and 80.77 %, respectively. Some cervical lymph nodes of the patients decreased in volume. The adverse reactions of this chemotherapy were minor.
Conclusion Continuous intra-arterial infusion chemotherapy via the superficial temporal artery resulted in good complete response for OSCC. Multiplechemotherapy was more effective than single chemotherapy, and there was no major adverse reaction. Thus, the primary tumor was easily ectomized.
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