干细胞因子HIWI在食管鳞癌中的表达及其与临床预后的关系

何炜; 解智慧; 王峰; 秦艳茹; 樊青霞

doi:10.3969/j.issn.1000-8179.2012.19.003

干细胞因子HIWI在食管鳞癌中的表达及其与临床预后的关系

Stem Cell Factor HIWI Expression in Human Esophageal Squamous Cell Carcinoma and Its Clinical Significance

摘要

摘要:
目的检测干细胞因子HIWI在食管鳞癌组织中的表达情况, 分析其表达与临床病理及预后的关系, 为食管癌的早期诊断和预后提供理论依据。
方法采用免疫组织化学法检测HIWI在153例食管鳞癌组织中的表达情况, 并结合食管鳞癌患者10年随访资料, 分析其表达与临床病理及预后的关系。
结果免疫组织化学结果显示, HIWI食管鳞癌细胞胞质和胞核中均有表达, 其在食管鳞癌细胞胞浆的表达水平与肿瘤的浸润深度(P=0.035, χ²=8.589)和组织学分级(P=0.011, χ²=9.075)呈正相关。Kaplan-Meier生存分析显示, 肿瘤细胞胞质高表达HIWI的患者的总生存情况明显差于胞浆低表达HIWI的患者(P < 0.001, χ²=17.05)。
结论干细胞因子HIWI在食管鳞癌细胞中有不同程度的表达, 且其在胞质中的表达水平是影响食管鳞癌预后的独立因素。

Abstract:
Objective To investigate the expression pattern of stem cell factor HIWI and the significance of this pattern in the diagnosis and prognosis of human esophageal squamous cell carcinoma(ESCC).
Methods The expression of HIWI in 153 esophageal squamous cell carcinoma specimens was characterized using immunohistochemistry.The correlations between the clinicopathological features and the expression of HIWI in esophageal squamous cancer were analyzed using crosstabs analysis.The survival curve regarding the expression of HIWI was analyzed using the Kaplan-Meier method.
Results HIWI immunoreactivity was observed in both the nucleus and cytoplasm of the ESCC.The expression level of HIWI in the cytoplasm was significantly associated with the histological grade(P=0.011, χ²=9.075) and the T stage(P=0.035, χ²=8.589).Patients with high HIWI expression tumors had poorer overall survival than those with low cytoplasmic expression tumors(P < 0.001, χ ²= 17.05).
Conclusion Higher cytoplasmic expression levels of stem cell factor HIWI in esophageal squamous carcinoma were significantly associated with higher histological grade and T stage, as well as poorer overall survival of the patients, making HIWI in cytoplasm an independent prognostic factor for survival.

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