Objective  The present study aims to evaluate the efficacy and side effects of nedaplatin(NDP) combined with coelom hyperthermic perfusion chemotherapy(CHPC) in treating patients with malignant pleural effusion.

  Methods  A total of 33 patients were randomized into two groups, namely, NDP group(n = 19) and diamminedichloroplatinum or cisplatin(DDP) group(n = 14).Pleural effusion from patients of both groups was drawn out of the thoracic cavity via the peripheral intravenous central catheter. CHPC and different drug medications were then administered.In the NDP group, 80 mg of NDP was administered to the pectoral cavity, whereas 80 mg of DDP was administered in the DDP group.Close attention was given to the patients to prevent and manage the side effects.

  Results  The response rate(RR) was 89.5%in the NDP group(17 /19), whereas the RR was 85.7%in the DDP group(12/ 14).No significant differences between the RR of the two groups were observed(P > 0.05).However, different effects in the gastrointestinal reactions were observed.The gastrointestinal reaction rate was lower in the NDP group(10.5%) compared with the DDP group(42.9%).No significant differences in the side effects in the medulla, liver, and nephridium were observed between the two groups(P > 0.05).Hydration and diuresis were not needed during NDP administration.

  Conclusion  The regimen of NDP combined with CHPC is effective in treating patients with malignant pleural effusion.Without hydration and diuresis in the treatment, this regimen has little toxicity and can be easily used for extensive clinical applications.