Abstract: Objective : A combination of intravenous and intra-arterial intensified chemotherapy was explored to improve preoperative chemotherapeutic efficacy. Cell cycle (phase)-specific drugs were administrated by slow intravenous infusion to prolong drug action time, whereas drugs that were not cell cycle-specific were administered via the celiac artery to improve local drug concentration. The FLEP regimen (i.e., intravenous 5-Fu and leucovorin, as well as intra-arterial etoposide and cisplatin) has been shown to be promising since its use for preoperative treatment of advanced gastric cancer in 2002. Cisplatin was replaced by oxaliplatin to reduce toxicity, and epirubicin was added to the local intra-arterial infusion such as the EAP regimen (i.e., etoposide, doxorubicin, and cisplatin) in more recent clinical practice. The FLEEOX regimen (i.e., 5-Fu, leucovorin, oxaliplatin, epirubicin, and etoposide) was then administered. With its powerful local therapeutic efficacy, this regimen has exhibited significant advantage in treating locally advanced gastric cancer over some conventional chemotherapeutic regimens, with more than 80% response rate.