Abstract: Objective: D2 radical gastrectomy is currently the standard operation for gastric cancer treatment. This operation requires a more extensive anatomic separation and resection compared with the conventional mode of surgery. Thus, intraoperative-related injury and postoperative complications are significantly increased during the radical gastrectomy. Surgery-related injury often includes injuries of the liver, spleen, pancreas, common bile duct, peri-gastric blood vessel, and lymphatic vessels. Several postoperativecomplications may occur, such as postoperative bleeding, acute cholecystitis, hydrops abdominis, and abscess. Surgeons who will perform the D2 operation should be skilled in surgical techniques and have adequate anatomical knowledge and satisfactory psychologicaldiathesis. Accurate judgment and correct management are necessary because surgery-related injury and postoperative complicationsmay occur. TRM staging system was superior to the TNM staging system for prognostic assessment of gastric cancer