Abstract:
Objective This work aims to investigate the mRNA and protein expressions of transforming acidic coiled-coil protein3 (TACC3) as well as its clinical significance in breast cancer.
Methods A total of 85 breast cancer tissues and paraneoplastic breast tissues were collected as samples. The mRNA and protein expressions of TACC3 in these tissue samples were determined using reverse transcription-polymerase chain reaction, western blot analysis, and immunohistochemical staining.
Results The mRNA and protein expressions of TACC3 were significantly higher in the breast cancer tissues than in the paraneoplastic breast tissues (P < 0.05). The TACC3 expressions were significantly correlated with the degrees of differentiation, tumor sizes, nodal metastasis, and tumor protein 53, but not with the ages of patients, menstrual status, and the expressions of estrogen receptor-positive, progesterone receptor-positive, human epidermal growth factor receptor-2, and Ki-67.
Conclusion TACC3 was overexpressed in breast cancer. This result is relevant to the clinicopathological features of the disease. Therefore, TACC3 expression may play a significant role in the onset and progression of breast cancer