Abstract:
Objective This study aims to evaluate the association between p73 G4C14-A4T14 polymorphisms and susceptibility to breast cancer in Chongqing women of Han Nationality in China.
Methods In a case-control study of 170 breast cancer patients and 178 healthy controls, single nucleotide polymorphisms(SNPs)of p73 G4C14-A4T14 at exon 2 were genotyped by the Sequenom Mass Array® iPLEX GOLD System.Data were analyzed via t-test, Chi-square test, and logistic regression analysis.
Results The distribution of p73 genotypes and allelotypes had no significant difference between the breast cancer patients and healthy controls(χ2=2.750, P=0.253;χ2=2.195, P=0.138).Individuals carrying the GC/GC genotype have a higher risk of developing triple negative breast cancer(TNBC)than individuals carrying the GC/AT and AT/AT genotypes(OR=2.992, 95%CI=1.300~6.890, P=0.010).
Conclusion p73 G4C14-A4T14 polymorphisms are closely associated with the increased risk for TNBC in Chongqing women of Han Nationality in China.The GC/GC genotype is susceptible to TNBC in Chongqing women of Han Nationality in China.Breast cancer patients carrying the GC/GC genotype may have bad prognosis.