肖炜明, 吴克艳, 龚卫娟, 卜平. 胃癌组织中CD1a+树突状细胞密度和血管内皮生长因子表达及其相关性[J]. 中国肿瘤临床, 2012, 39(21): 1623-1625, 1634. DOI: 10.3969/j.issn.1000-8179.2012.21.015
引用本文: 肖炜明, 吴克艳, 龚卫娟, 卜平. 胃癌组织中CD1a+树突状细胞密度和血管内皮生长因子表达及其相关性[J]. 中国肿瘤临床, 2012, 39(21): 1623-1625, 1634. DOI: 10.3969/j.issn.1000-8179.2012.21.015
shu
Weiming XIAO, Keyan WU, Weijuan GONG, Ping BU. Detection of CD1a+ Positive Dendritic Cells and VEGF Expression and Their Correlation in Gastric Carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(21): 1623-1625, 1634. DOI: 10.3969/j.issn.1000-8179.2012.21.015
Citation: Weiming XIAO, Keyan WU, Weijuan GONG, Ping BU. Detection of CD1a+ Positive Dendritic Cells and VEGF Expression and Their Correlation in Gastric Carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(21): 1623-1625, 1634. DOI: 10.3969/j.issn.1000-8179.2012.21.015
shu

胃癌组织中CD1a+树突状细胞密度和血管内皮生长因子表达及其相关性

Detection of CD1a+ Positive Dendritic Cells and VEGF Expression and Their Correlation in Gastric Carcinoma

    摘要
  • 摘要:
      目的  探讨胃癌组织中CD1a+树突状细胞密度和VEGF表达及其与胃癌临床病理特征间的关系, 并探究其在胃癌组织中表达的相关性。
      方法  采用免疫组织化学双染法检测60例胃癌组织及相应癌旁组织中CD1a+DCs、VEGF的表达。
      结果  胃癌组织中CD1a+DCs浸润密度略低于癌旁组织(P > 0.05), 但差异无统计学意义; 胃癌中CD1a+DCs密度与浸润深度、肿瘤分化、TNM分期程度有关(P < 0.05)。胃癌组织VEGF的阳性表达率明显高于癌旁组织(P < 0.01), 胃癌中VEGF的表达与肿块大小(P < 0.05)、浸润深度、淋巴结转移、TNM分期程度有关(P < 0.01)。CD1a+DCs与VEGF表达呈负相关(r=-3.08, P < 0.01)。
      结论  CD1a+DCs随着胃癌恶性程度增加和肿瘤的进展而减少; VEGF在胃癌组织中高表达, VEGF的表达随着胃癌的进展而增高, 对其表达与检测有助于判断胃癌的预后。

     

    Abstract:
      Objective  This study aims to observe the density of CD1a+DCs and VEGF expression level and their correlation in gastric carcinoma.In addition, the correlation of CD1a+DCs and VEGF expression with the clinico-pathological characteristics of gastric carcinoma was simultaneously studied.
      Methods  The expressions of CD1a and VEGF in paraffin-embedded samples from 60 gastric carcinoma tissues and 20 paired cancer-adjacent tissues were double-stained via the immunohistochemical method.
      Results  The infiltrating density of CD1a+DCs in gastric carcinoma correlated with depth of invasion, patho-type of tumor, and TNM classification(P < 0.05).The expression level of VEGF was significantly higher than that of normal mucosa(P < 0.01).The expression level of VEGF also correlated with tumor sizes(P < 0.05), depth of invasion, lymph node metastasis, and TNM classification(P < 0.01).The density of CDla+ DCs negatively correlated with VEGF expression(r=-3.08, P < 0.01).
      Conclusion  The lower density of CD1a+DCs was associ-iated with a higher grade of malignancy and progression of gastric carcinoma.VEGF was highly expressed in gastric carcinoma, which is linked with development of gastric carcinoma.Therefore, both the density of CD1a+DCs and VEGF expression level may serve as prognostic factors in gastric carcinoma.

     

    • HTML全文
    • 参考文献(14)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回