Abstract:
Objective To investigate the expression of SSTR2 and SSTR5 in non-small cell lung cancer, and explore their relationship with angiogenesis, clinical parameters, and prognosis.
Methods Immunohistochemical staining was used to detect the expression of SSTR2 and SSTR5 proteins in 54 cases of NSCLC and 21 tumor-adjacent normal lung tissues.The microvessels were immuno-histochemically labeled with anti-CD34 antibody to assess microvessel density.
Results In the NSCLC tissues, the expression rates of SSTR2 and SSTR5 proteins were 51.9%(28/54)and 55.6%(30/54), respectively.Meanwhile, in the tumor-adjacent normal lung tissues, the positive rates of SSTR2 and SSTR5 were 14.3%(3/21)and 19.0%(4/21), respectively.The difference was statistically significant (P < 0.05).The expression of SSTR2 and SSTR5 proteins was closely related to TNM stage(P < 0.05), but insignificantly related to patient age, sex, smoking history, pathological type, differentiation grade, tumor size, and lymph node metastasis(P > 0.05).Increased MVD was correlated to lymph node metastasis and advanced stage(Ⅲ~Ⅳ)(P < 0.05), but uncorrelated to patient age, sex, smoking history, pathological type, differentiation grade, and tumor size(P > 0.05).The three-year survival rates were 70.4%and 66.1%in patients who are positive of SSTR2 and SSTR5, respectively, and 35.3%and 37.3%in those who are negative of the two proteins.There was a negative correlation between MVD with the expression of SSTR2 and SSTR5 in the NSCLC tissues(P < 0.05).
Conclusion The MVD increased along with the progression of NSCLC.The expression of SSTR2 and SSTR5 proteins was negatively related to angiogenesis and may suggest a good prognosis.