Abstract:
Objective To analyze the prognostic factors in the resection of stageⅠto stageⅢadenosquamous lung carcinoma.
Methods From January 1994 to December 2008, 181 surgically treated patients with adenosquamous lung carcinoma were retrospectively investigated based on the 2009 International Association for the Study of Lung Cancer(IASLC)tumor-lymph node-metastasis classification.The correlation between clinicopathologic characteristics and prognosis was evaluated using univariate and multivariate analyses.
Results The overall 3-and 5-year survival rates were 30.9%and 19.0%, respectively, and the median survival time was 23.0 months.By univariate analysis, lymph node resection approach, tumor(T)stage, lymph node stage, and the number of chemotherapy cycles were significantly related to patient survival(P < 0.05).By multivariate analysis, lymph node resection approach(P=0.046).T stage(P=0.006), N stage(P < 0.001), and the number of chemotherapy cycles(P=0.031)were independent prognostic factors.
Conclusion The overall survival rate of adenosquamous lung carcinoma was low.Radical systematic mediastinal lymphadenectomy is the surgical treatment of choice for adenosquamous lung carcinoma.The survival rates at stages T1 to T4 gradually decreased.The patients without lymph node involvement(NO)had longer survival periods than those with N1 and N2 lymph node involvement.Chemotherapy significant improves the survival of patients with stageⅢdisease.Chemotherapy cycle should consist of at least 4 cycles.