Abstract:
Objective This work investigated the effect of cavity circulatory thermal perfusion (CCTP) on the vital signs and important organs of the experimental animal dogs at different temperatures. The study likewise aimed to determine the optimal temperature for chemotherapy.
Methods Dogs were used as the experimental animal models for CCTP. CCTP was performed with cisplatin using a hyperthermic intraperitoneal treatment system at 41℃, 42℃, and 43℃ (one course of clinical treatment). The hepatic and renal functions were detected in preserved blood samples before CCTP and at 24 h after each course of the treatment. The respective morphological and pathological changes of the major abdominal organs were likewise studied at 24 h as well as 2 weeks after the third course of CCTP.
Results The three courses of CCTP with a perfusion rate of 140 mL/min at 41 or 42℃ did not have any observable negative effects on the hepatic and renal functions of experimental animals. On the other hand, the three courses of CCTP with a perfusion rate of 140 mL/min at 43℃ had a significant negative effect on the hepatic and renal functions, with histopathological injuries in the liver, kidney, spleen, and intestines.
Conclusion CCTP with a perfusion rate of 140 mL/min combined with cisplatin chemotherapy (three times /60 min) was safe and feasible at 42℃, but could damage visceral organs of experimental animals at 43℃.
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