闫哲. 胱蛋白M在乳腺癌及其转移癌中的表达和临床意义[J]. 中国肿瘤临床, 2012, 39(22): 1792-1795. DOI: 10.3969/j.issn.1000-8179.2012.22.025
引用本文: 闫哲. 胱蛋白M在乳腺癌及其转移癌中的表达和临床意义[J]. 中国肿瘤临床, 2012, 39(22): 1792-1795. DOI: 10.3969/j.issn.1000-8179.2012.22.025
shu
Zhe YAN. Expression and Clinical Significance of Cystatin M in Breast Cancer and Metastatic Cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(22): 1792-1795. DOI: 10.3969/j.issn.1000-8179.2012.22.025
Citation: Zhe YAN. Expression and Clinical Significance of Cystatin M in Breast Cancer and Metastatic Cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(22): 1792-1795. DOI: 10.3969/j.issn.1000-8179.2012.22.025
shu

胱蛋白M在乳腺癌及其转移癌中的表达和临床意义

Expression and Clinical Significance of Cystatin M in Breast Cancer and Metastatic Cancer

    摘要
  • 摘要:
      目的   探讨胱蛋白M（Cystatin M）在乳腺癌及转移癌中的表达和临床意义。
      方法  采用RT-PCR检测108例乳腺癌标本，30例转移癌标本及24例癌旁正常乳腺组织中Cystatin M mRNA，分析Cystatin M基因表达与临床病理参数和预后的关系。
      结果  乳腺癌标本中Cystatin M表达水平在Ⅰ/Ⅱ期乳腺癌患者中较高，而在Ⅲ/Ⅳ期乳腺癌患者中较低，差异有统计学意义；Cystatin M在5 cm以下肿瘤中表达较高，而在5 cm以上肿瘤中表达较低，差异有统计学意义；乳腺癌标本中Cystatin M表达与正常乳腺组织中Cystatin M表达差异无统计学意义；乳腺癌标本中Cystatin M与转移癌标本中Cystatin M表达差异无统计学意义；乳腺癌标本中Cystatin M表达水平与乳腺癌患者是否发生淋巴结转移，淋巴结转移数，组织学分级，病理学类型无相关性；乳腺癌标本中Cystatin M表达水平和转移癌标本中Cystatin M表达水平与人表皮生长因子受体2状态（HER-2），雌激素受体状态（ER）及孕激素受体状态（PR）无相关性；乳腺癌标本中Cystatin M表达较高的组患者中位总生存期比Cystatin M表达较低的组患者中位总生存期要长，两者之间差异无统计学意义。
      结论  Cystatin M为监测乳腺癌发生浸润转移的可靠指标仍需探讨。

     

    Abstract:
      Objective   This study aims to explore the expression and clinical significance of cystatin M in breast cancer.
      Methods  Reverse transcription polymerase chain reaction was used to measure the level of cystatin M mRNA in 108 samples of breast cancer, 30 metastatic cancer, and 24 normal breast tissues. The relationship between the expression of cystatin M gene in human breast cancer and the clinilcopathological features was analyzed.
      Results  The cystatin M expression levels in breast cancer are correlated with TNM staging and clinical size of the tumor. The expression levels of cystatin M in breast cancer tissue are not significantly different from normal breast tissues and metastatic cancer tissues. Cystatin M expression levels in breast cancer are not correlated with lymph node metastasis, axillary lymph node status, histological grade, or pathological type. Cystatin M expression levels in breast cancer and metastatic cancer are not correlated with Her-2, ER, or PR status. Cystatin M expression levels in breast cancer are correlated with the overall survival.
      Conclusions  Whether cystatin M can be used as a prognostic marker for breast cancer metastasis still needs further studies.

     

    • HTML全文
    • 参考文献(12)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回