Abstract:
Objective This work aims to analyze the relationship between local recurrence and location of the tumor in early glottic carcinoma after CO2 laser endoscopic resection.
Methods Data of 133 early glottic carcinoma cases, which were treated with laser surgery and were hospitalized at the cancer center of Sun Yan-Sen University from 2008 to 2010, were reviewed retrospectively. Of the 133 cases, 48 involved the anterior commissure and the other 85 did not. Of the total cases, Tis stage lesion (tumor in situ) was found in 58 cases, T1a stage in 58, T1b stage in 19, T2 stage in 15, and T3 stage in only 1. The follow-up period ranged from 6 to 42 months. The local recurrence rate between the involvement and non-involvement of anterior commissure was compared.
Results Local recurrence was detected in 21 of the 133 cases with early glottic laryngeal carcinoma after CO2 laser surgery. The local recurrence rate was 15.79%(21/133). The recurrence rates of T1a, T1b, T2, and T3 were 8.62%, 36.84%, 13.33%, and 0%, respectively. No significant difference was found among the four groups (P≥0.05). Among the 135 patients presenting with early glottic cancer, the anterior commissure was involved in 48 cases, with a local recurrence rate of 25% (12/48). In 85 of the cases without anterior commissure involvement, the local recurrence rate was 10.59% (9/85). Significant differences were found between the two groups (P≤0.05). Of the 133 patients who received CO2 laser surgery as the only therapy, 129 survived and 4 died.
Conclusion After laser microsurgery of early glottic carcinoma, a higher rate of tumor recurrence was found in the lesions with anterior commissure involvement. This finding needs further research.
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