Abstract:
Objective This study aimed to analyze the systemic treatment and prognosis of hemangiopericytoma (HPC).
Methods Clinical data of 29 patients (19 males and 10 females) who were treated in the Cancer Hospital of Tianjin Medical University between April 1966 and August 2011 were reviewed. The median age of the patients was 42 years (range: 7 months to 75 years). The total number of primary tumor was 31 and the median tumor size was 5.2 cm × 4.6 cm.
Results The overall median survival rate among the 29 patients was 51 months (range: 5 to 252 months); and the 1-, 3-, 5-, and 10-year survival rates of the patients were 93.1%, 76.5%, 67.5%, and 52.5%, respectively. The 1-, 5-, and 10-year survival rates of the patients who received adjuvant radiotherapy and those who did not receive adjuvant radiotherapy were 100%, 87.5%, and 69.3% as well as 89.5%, 56.8%, and 34.1%, respectively. Eleven patients (44%) had HPC recurrence and the median local recurrence time was 9.5 months (range: 4 to 120 months). Patients who received adjuvant radiotherapy after resection had a lower local recurrence rate (P=0.042) compared with those who did not receive adjuvant radiotherapy. No difference was found between the two groups (P=0.673) when distant metastases were considered. Adjuvant chemotherapy neither reduced the distant metastatic rates nor extended the overall survival rate.
Conclusion Adjuvant radiotherapy can reduce the local recurrence rate and may improve the overall survival rate of HPC patients.