Abstract:
Objective This work aimed to analyze the clinicopathological characteristics and prognostic factors of biliary tract cancer patients who had undergone surgery.
Methods The medical records of 116 patients with biliary tract cancer who had undergone radical surgery in Tianjin Cancer Hospital between January 2006 and December 2010 were retrospectively analyzed. The clinicopathological characteristics and prognostic factors were analyzed.
Results Univariate analysis revealed that the liver invasion, tumor grading, lymphatic/ vascular invasion, lymph node staging, tumor–node–metastasis classification of the World Health Organization, and adjuvant chemotherapy were associated with the prognosis of these patients. Multivariate analysis revealed that the tumor grades and adjuvant chemotherapy were the independent prognosis factors. The responses to adjuvant chemotherapy also varied with the tumor location.
Conclusion Tumor grading and adjuvant chemotherapy were independent prognosis factors of biliary tract cancer patients. Their biological behaviors and responses to adjuvant chemotherapy varied with the tumor location. These behaviors and responses may need to be separately considered and analyzed for effective individualized treatment.