王博, 张传平, 张舒, 岳恺, 王旭东. EMT介导口腔鳞癌淋巴结转移及其机制研究[J]. 中国肿瘤临床, 2012, 39(23): 1877-1880,1885. DOI: 10.3969/j.issn.1000-8179.2012.23.003
引用本文: 王博, 张传平, 张舒, 岳恺, 王旭东. EMT介导口腔鳞癌淋巴结转移及其机制研究[J]. 中国肿瘤临床, 2012, 39(23): 1877-1880,1885. DOI: 10.3969/j.issn.1000-8179.2012.23.003
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Bo WANG, Chuanping ZHANG, Shu ZHANG, Kai YUE, Xudong WANG. Epithelial-Mesenchymal Transformation-Mediated Lymph Node Metastasis of Oral Squamous Cell Carcinoma and Its Mechanism[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(23): 1877-1880,1885. DOI: 10.3969/j.issn.1000-8179.2012.23.003
Citation: Bo WANG, Chuanping ZHANG, Shu ZHANG, Kai YUE, Xudong WANG. Epithelial-Mesenchymal Transformation-Mediated Lymph Node Metastasis of Oral Squamous Cell Carcinoma and Its Mechanism[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(23): 1877-1880,1885. DOI: 10.3969/j.issn.1000-8179.2012.23.003
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EMT介导口腔鳞癌淋巴结转移及其机制研究

Epithelial-Mesenchymal Transformation-Mediated Lymph Node Metastasis of Oral Squamous Cell Carcinoma and Its Mechanism

    摘要
  • 摘要:
      目的  探讨EMT在口腔鳞癌淋巴结转移中的作用及其调控机制。
      方法  应用免疫组织化学SP法检测CXCR4及EMT相关因子在60例口腔鳞癌中的的表达，应用χ2或Fisher确切概率法分析各指标与口腔鳞癌患者临床病理资料的关系、Spearman相关性分析CXCR4与EMT相关因子的相关性。
      结果   χ2或Fisher确切概率法检验显示CXCR4、β-catenin、E-cadherin、N-cadherin、Twist、Snail在淋巴结转组与非淋巴结转移组中表达的差异有统计学意义（P < 0.05），且CXCR4与分化程度有关，β-catenin与分化程度及T分期有关，E-cadherin与原发部位及分化程度有关，Twist与分化程度有关（P < 0.05）。Spearman分析显示β-catenin的表达与CXCR4呈负相关，相关系数为-0.497；Snail、Twist、N-cadherin的表达与CXCR4呈正相关，相关系数分别为0.256、0.300、0.333（P < 0.05）。
      结论   提示EMT在口腔鳞癌的淋巴结转移过程中发挥重要作用，CXCL12/CXCR4生物学轴可能作用于EMT的某个环节，并调控其发生

     

    Abstract:
      Objective   This study was performed to investigate the role of epithelial-mesenchymal transformation (EMT) in the lymph node metastasis of oral squamous cell carcinoma (OSCC) and its regulatory mechanism.
      Methods   The expression of the Chemokine C-X-C motif receptor 4 (CXCR4) and EMT-related factors in 60 cases with OSCC was analyzed via immunohistochemical assay. The χ2 or Fisher's exact probability test was used to analyze the relationship between the expression of EMT-related factors and clinico-pathologic data of the OSCC patients. Spearman correlation analysis was used to analyze the correlation between CXCR4 and EMT-related factors.
      Results   The results of the χ2 or Fisher's exact probability test showed that the expression of CXCR4, β-catenin, E-cadherin, N-cadherin, Twist, and Snail in the groups with and without lymph-node metastasis were statistically significant (P < 0.05). Moreover, a statistical correlation exists between CXCR4 and the degree of differentiation. A correlation was also found among β-catenin, the degree of differentiation, and T staging. Moreover, a similar relationship was found among E-cadherin, tumor site, and the degree of differentiation, as well as between Twist and the degree of differentiation (P < 0.05). The Spearman analysis showed that the expression of CXCR4 has a negative correlation between the expression of CXCR4 and β-catenin. The correlation coefficient was -0.497. However, a positive correlation among the expression of CXCR4 with Twist, Snail, and N-cadherin was observed, with correlation coefficients of 0.256, 0.300, and 0.333, respectively (P < 0.05).
      Conclusion   EMT has an important function in the lymph node metastasis of OSCC. The CXCL12/CXCR4 biological axis may act on a particular EMT function and regulate the occurrence of EMT.

     

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