I 125放射性粒子植入在口腔颌面部恶性肿瘤治疗中的应用

张素欣,  陈彦平,  刘哲敏,  段玉芹,  陈中,  郭兰涛,  郑晶,  李天客

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张素欣, 陈彦平, 刘哲敏, 段玉芹, 陈中, 郭兰涛, 郑晶, 李天客. I 125放射性粒子植入在口腔颌面部恶性肿瘤治疗中的应用[J]. 中国肿瘤临床, 2012, 39(23): 1943-1945. doi: 10.3969/j.issn.1000-8179.2012.23.018
引用本文: 张素欣, 陈彦平, 刘哲敏, 段玉芹, 陈中, 郭兰涛, 郑晶, 李天客. I 125放射性粒子植入在口腔颌面部恶性肿瘤治疗中的应用[J]. 中国肿瘤临床, 2012, 39(23): 1943-1945. doi: 10.3969/j.issn.1000-8179.2012.23.018
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Suxin ZHANG, Yanping CHEN, Zhemin LIU, Yuqin DUAN, Zhong CHEN, Lantao GUO, Jing ZHENG, Tianke LI. I 125 Seed Implantation in Treatment of Oral and Maxillofacial Malignancy[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(23): 1943-1945. doi: 10.3969/j.issn.1000-8179.2012.23.018
Citation: Suxin ZHANG, Yanping CHEN, Zhemin LIU, Yuqin DUAN, Zhong CHEN, Lantao GUO, Jing ZHENG, Tianke LI. I 125 Seed Implantation in Treatment of Oral and Maxillofacial Malignancy[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(23): 1943-1945. doi: 10.3969/j.issn.1000-8179.2012.23.018
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I 125放射性粒子植入在口腔颌面部恶性肿瘤治疗中的应用

doi: 10.3969/j.issn.1000-8179.2012.23.018

  • 河北医科大学第四医院口腔科（石家庄市050017）

基金项目: 

河北省教育厅高校强势学科肿瘤学科项目 JiJiaoGao[2005] No.52

详细信息
    通讯作者:

    段玉芹    dhp1954@hotmail.com

I 125 Seed Implantation in Treatment of Oral and Maxillofacial Malignancy

  • Department of Stomatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050017, China

Funds: 

the Hebei Provincial Program for Subjects with High Scholarship and Creative Research Potential JiJiaoGao[2005] No.52

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    摘要
  • 摘要:   目的  研究I125放射性粒子组织间近距离植入治疗口腔颌面部恶性肿瘤的近期疗效及副反应, 探讨其在恶性肿瘤综合治疗中的应用价值。   方法  根据制定的相应放射性粒子植入治疗计划, 对38例口腔颌面部恶性肿瘤患者应用手术配合I125粒子植入治疗或单纯粒子植入治疗, 术后随访观察疗效及副反应。   结果  所有病例随访12~28个月, 平均20个月, 其中23例手术配合粒子植入者局部未见明显新生肿物, 15例单纯粒子植入病例均见病灶不同程度缩小, 不适症状有所减轻。除2例患者出现局部皮肤色素沉着, 1例患者咽部不适1周后缓解, 余病例均未出现明显粒子植入后副反应。   结论  放射性粒子植入治疗对口腔颌面部恶性肿瘤的近期疗效显著, 为综合治疗口腔颌面部恶性肿瘤提供了新的发展方向。

     

    Abstract:   Objective  This paper aims to study the therapeutic results and side effects of I125 seed implantation for malignant oral and maxillofacial tumors and to discuss the value of seed implantation in the treatment of malignant tumors.   Methods  According to the treatment plan system (TPS), 38 patients with oral and maxillofacial malignancies were treated using I125 seed implant with or without operation. All patients were followed up and their results evaluated.   Results   No recurrence was observed during the 12 months to 28 months (average 20 months) of follow up among the 23 patients who were implanted during or after the operation. The size of all tumors decreased and the symptoms were alleviated in 15 other patients who received only radioactive seed implantation. No obvious side effects aside from skin pigmentation occurred in 2 patients, whereas throat discomfort occurred in 1 patient.   Conclusion   Radioactive seed implantation is very effective for malignant oral and maxillofacial tumors. The technique provides a new way of treating oral and maxillofacial malignancies.

     

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  • 图  1  腮腺恶性肿瘤患者放射性粒子植入术前及术后CT影像比较

    A：术前；B：术后

    Figure  1.  The comparison of CT image before and after radioactive parti⁃ cles implantation in patients with parotid malignant tumors

    下载: 全尺寸图片 幻灯片

    图  2  腮腺恶性肿瘤患者粒子植入术中插植定位

    Figure  2.  Particle implantation pictures in patients with parotid malignant tumors

    下载: 全尺寸图片 幻灯片
    • 参考文献(10)
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    [6] Zhang J, Zhang JG, Song TL, et al. I125 seed implant brachytherapy-assisted surgery with preservation of the facial nerve for treatment of malignant parotid gland tumors[J]. Int J Oral Maxil Surg, 2008, 37(6): 515-520. doi: 10.1016/j.ijom.2008.04.013
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  • 收稿日期:  2011-10-12
  • 修回日期:  2012-04-23

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