乳腺癌患者SBEM表达及临床意义的研究进展

刘良; 谢晓冬

doi:10.3969/j.issn.1000-8179.2012.23.029

乳腺癌患者SBEM表达及临床意义的研究进展

doi: 10.3969/j.issn.1000-8179.2012.23.029

刘良^{①, ②},
谢晓冬^①, ,

①.
沈阳军区总医院全军肿瘤诊治中心肿瘤科（沈阳市110840）
②.
辽宁医学院研究生院

详细信息

通讯作者:
谢晓东 xiexiaodong@csco.org.cn

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出版历程
- 收稿日期: 2012-01-13
- 修回日期: 2012-03-30

Research Progress on Expression and Clinical Significance of SBEM in Breast Cancer Patients

Liang LIU^{①, ②},
Xiaodong XIE^{①
, ,}

①.
Department of Oncology, the General Hospital of Shenyang Military Command of PLA, Shenyang 110840, China
②.
Graduate School of Liaoning Medical University, Jinzhou 110001, China

More Information

Corresponding author: Xiaodong XIE; E-mail: xiexiaodong@csco.org.cn

摘要

摘要: 乳腺小黏蛋白(small hreast epithelialmucin, SBEM)是一种分泌性蛋白, 仅在乳腺及唾液中表达, 可作为乳腺癌患者微转移的分子标志物及其治疗的特异性靶标。SBEM在乳腺癌组织中蛋白水平检出率最高达51%, 在外周血中mRNA水平检出率最高达53.3%, 且与乳腺癌患者的TNM分期直接相关。SBEM-mRNA与角蛋白19 mRNA(CK19-mRNA)、泌乳素诱导蛋白(PIP-mRNA)及癌胚抗原(CEA)的联合检测, 能够提高乳腺癌患者微转移的检出率及敏感度和准确度, SBEM-mRNA表达水平变化的检测可应用于新辅助化疗疗效预测, 并对骨髓微转移的诊断具有特异性和准确性, 且与肿瘤的分期密切相关, 在临床中有较好的应用前景。本文就SBEM的表达、与临床病理参数的关系、联合检测的意义及其应用价值等做一综述。
- 乳腺癌 /
- SBEM /
- SBEM-mRNA /
- 微转移
Abstract: Small breast epithelial mucin (SBEM) is a kind of secreted protein expressed only in the mammary and salivary glands. It can be used as a tumor marker to detect the micro-metastasis in breast cancer and specific target in the treatment. The detection rate of SBEM is up to 51% in breast cancer tissue and that of SBEM-mRNA is 53.3% in the peripheral blood, which has a direct correlation with the TNM stage. The detection rate of micro-metastasis and sensitivity and accuracy in breast cancer can be improved by a combined assay with multiple genes, such as CK19-mRNA, PIP-mRNA, CEA, and MGA. The change of expression level could predict the curative effect of neo-adjuvant chemotherapy. SBEM-mRNA exhibits sensitivity and accuracy in the bone marrow micro-metastases of breast cancer, and has a direct correlation with the TNM stage. The detection of SBEM would have a better prospect for application because of its clear advantage in detecting the micro-metastasis of breast cancer and clinical supervision. The expression and correlation with the clinico-pathological features, the significance of the combined assay with multiple genes, as well as the value of clinical applications of SBEM-mRNA were reviewed in this paper.
- Breast cancer /
- SBEM /
- SBEM-mRNA /
- Micro-metastasis

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