8q24染色体rs1447295A/C多态性与前列腺癌发病风险

杨震宇; 盛畅

doi:10.3969/j.issn.1000-8179.2012.23.030

8q24染色体rs1447295A/C多态性与前列腺癌发病风险

doi: 10.3969/j.issn.1000-8179.2012.23.030

杨震宇^,,
盛畅

上海市浦东新区人民医院泌尿外科（上海市 201200）

详细信息

通讯作者:
杨震宇 zhenyuyang@live.cn

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- 被引次数: 0
出版历程
- 收稿日期: 2011-07-19
- 修回日期: 2012-01-03

Association between 8q24 rs1447295A/C Polymorphisms and the Risk of Prostate Cancer

Zhenyu YANG^,,
Chang SHENG

Department of Urological Surgery, People's Hospital of Pudong (New Area), Shanghai 201200, China

More Information

Corresponding author: Zhenyu YANG; E-mail: zhenyuyang@live.cn

摘要

摘要: 最近全基因组关联研究发现染色体8q24区的遗传改变与前列腺发病风险有关, 其中rs1447295A/C多态性与前列腺癌发病风险尤其被关注。目前已经在不同人群中进行了研究, 包括欧洲人、非洲人、亚洲人以及其后裔。多数研究均证实8q24染色体rs1447295A/C多态性与前列腺癌发病风险显著相关。本文围绕近年来有关8q24染色体中rs1447295A/C多态性与前列腺癌发病风险的研究进行综述。
- 前列腺癌 /
- 8q24染色体 /
- rs1447295 /
- 多态性
Abstract: Genome-wide association studies have revealed a correlation between the hereditary change in the chromosome 8q24 zone and the risk of prostate cancer (PCa). The various single nucleotide polymorphisms are of considerable interest, particularly the rs1447295A/C polymorphism, which has been studied in different populations, including Europeans, Africans, Asians, and their descendants. Large-scale studies have confirmed the remarkably strong association of the rs 1447295A/C polymorphism with the risk of PCa. Recent advances in the relationship between the rs1447295A/C polymorphism in chromosome 8q24 and the risk of PCa were reviewed in this paper.
- Prostatic neoplasms /
- Chromosome 8q24 /
- rs1447295 /
- Polymorphism

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参考文献(24)

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