翁克贵, 吴伟莉, 金风, 陈海霞, 李媛媛, 龙金华, 陈潇潇, 刘梅, 戚正君, 雷鹰. 动态增强磁共振预测鼻咽癌原发灶化疗疗效的临床研究[J]. 中国肿瘤临床, 2012, 39(24): 2036-2039. DOI: 10.3969/j.issn.1000-8179.2012.24.012
引用本文: 翁克贵, 吴伟莉, 金风, 陈海霞, 李媛媛, 龙金华, 陈潇潇, 刘梅, 戚正君, 雷鹰. 动态增强磁共振预测鼻咽癌原发灶化疗疗效的临床研究[J]. 中国肿瘤临床, 2012, 39(24): 2036-2039. DOI: 10.3969/j.issn.1000-8179.2012.24.012
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Kegui WENG, Weili WU, Feng JIN, Haixia CHEN, Yuanyuan LI, Jinhua LONG, Xiaoxiao CHEN, Mei LIU, Zhengjun QI, Ying LEI. Clinical Studies on the Prediction of Chemotherapeutic Efficacy for the Primary Lesion of Nasopharyngeal Carcinoma by Dynamic Contrast-Enhanced Magnetic Resonance[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(24): 2036-2039. DOI: 10.3969/j.issn.1000-8179.2012.24.012
Citation: Kegui WENG, Weili WU, Feng JIN, Haixia CHEN, Yuanyuan LI, Jinhua LONG, Xiaoxiao CHEN, Mei LIU, Zhengjun QI, Ying LEI. Clinical Studies on the Prediction of Chemotherapeutic Efficacy for the Primary Lesion of Nasopharyngeal Carcinoma by Dynamic Contrast-Enhanced Magnetic Resonance[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2012, 39(24): 2036-2039. DOI: 10.3969/j.issn.1000-8179.2012.24.012
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动态增强磁共振预测鼻咽癌原发灶化疗疗效的临床研究

Clinical Studies on the Prediction of Chemotherapeutic Efficacy for the Primary Lesion of Nasopharyngeal Carcinoma by Dynamic Contrast-Enhanced Magnetic Resonance

    摘要
  • 摘要:
      目的  探讨动态增强磁共振成像在局部晚期鼻咽癌化疗疗效预测中的价值，为进行个体化治疗提供依据。
      方法  64例2010UICC分期为Ⅲ~Ⅳb期的初治鼻咽癌患者，行TPF方案诱导化疗3周期。诱导化疗前行DCE-MR检查，获取造影剂到达组织时间（T1 on set），造影剂到达强化高峰时间（TTP），最大信号强度值（SI），强化峰值（PV），强化百分数（SI%）等参数, 将其与诱导化疗后肿瘤缩小率进行相关性分析。
      结果  1）诱导化疗后鼻咽癌原发灶PR24例，NC40例。2）鼻咽癌原发灶缩小率与T1 on set（r=-0.378，P < 0.001）及TTP（r=-0.285，P=0.02）负相关；与SI（r=0.027，P=0.834）、PV（r=0.042，P=0.741）、SI%（r=0.026，P=0.841）无明确相关关系。
      结论  造影剂到达组织及达到强化高峰时间早的病例化疗后肿瘤缩小率大；肿瘤强化程度与化疗后肿瘤缩小率无相关性；T1 on set、TTP有可能作为鼻咽癌化疗疗效预测指标之一。

     

    Abstract:
      Objective  To investigate the value of dynamic contrast-enhanced magnetic resonance (DCE-MR) in predicting the chemotherapy efficacy of locally advanced nasopharyngeal carcinoma, thereby providing a more reliable basis for making personalized treatment plans.
      Methods  Sixty-four patients were pathologically diagnosed as having nasopharyngeal carcinoma in stage Ⅲ-Ⅳb 2010UICC.They were treated by TPF regimen (Docetaxel+Cisplatin+ 5-Fluorouracil) in 3 cycles. Before undergoing induction chemotherapy, they received DCM-MRI to obtain the time at arrival of contrast inflow (T1 on set), time to peak (TTP), maximum of signal intensity (SI), peak value (PV), and percent of signal intensity (SI%). The relationship between DCM-MR parameters and tumor regression rate after induction chemotherapy is investigated.
      Results  1) A total of 24 cases achieved PR and 40 cases achieved NC. 2)T1 on set and TTP negatively correlated to regression rate of primary tumor (-0.378 and -0.285, P < 0.001 and P=0.02). PV (0.027, P=0.834), SI (0.042, P=0.741), and SI%(0.026, P = 0.841) have no correlation with tumor regression rate.
      Conclusion  1) Patients with sooner T1 on set and TTP have a greater tumor regression rate. 2)Tumor enhancement degree and tumor regression rate after chemotherapy have no correlation. 3)DCM-MR parameters, such as TTP and T1 on set, can be used to predict the curative effect of induction chemotherapy.

     

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