康莱特联合放疗治疗老年局部晚期非小细胞肺癌疗效观察

李莉; 张洪珍; 戴福生; 邱刚; 房保栓

doi:10.3969/j.issn.1000-8179.2012.24.031

康莱特联合放疗治疗老年局部晚期非小细胞肺癌疗效观察

Observation on the Therapeutic Effects of Kang Lai Te Injection for Locally Advanced Lung Cancer on Radiotherapy Treatment

摘要

摘要:
目的探讨康莱特注射液在老年晚期肺癌患者放疗中的作用。
方法回顾分析108例老年Ⅲ期非小细胞肺癌（NSCLC）患者两种治疗方法，其中单纯放疗56例，采用常规分割，总剂量60~66 Gy/6~7周；康莱特联合放疗52例，放疗同时静脉注射康莱特。
结果治疗后两组患者症状及Karnofsky评分均有改善，康莱特组比单纯放疗组改善更明显；单放组、康莱特组完全缓解（CR）率分别为17.9%、36.5%；总有效率（PR+CR）分别为42.9%、67.7%。康莱特组放射性肺炎及食管炎发生率明显低于单放组。
结论康莱特联合放疗治疗老年局部晚期肺癌可提高临床疗效, 减少不良反应的发生, 适合老年肺癌患者的辅助治疗。

Abstract:
Objective This study aimed to observe the effect of Kang Lai Te (KLT) injection for locally advanced lung cancer on radiotherapy treatment.
Methods Data of 108 elderly patients with stage Ⅲ lung cancer who failed to undergo chemotherapy were retrospectively analyzed. The patients were divided into two groups, the treatment group A with simple radiotherapy (56 cases) and the treatment group B with radiotherapy based on the application of KLT injection (52 cases).
Results After the treatments were performed, the total effective rates were 42.9% and 67.7% in groups A and B, respectively. A significant difference was found between the two groups. Karnofsky scores and the occurrence of adverse reactions were also significantly different (P < 0.05).
Conclusion Radiotherapy based on the application of KLT treatment for elderly patients with advanced lung cancer can significantly improve the clinical effect and the quality of life of patients as well as reduce the incidence of adverse reactions.

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