张岳林, 孙军辉, 聂春晖, 陈黎明, 蔡丽霞, 何建娣, 章丽霞, 王伟林, 郑树森. 肝动脉化疗栓塞次数对肝癌根治术后复发的影响[J]. 中国肿瘤临床, 2013, 40(16): 975-978. DOI: 10.3969/j.issn.1000-8179.20121406
引用本文: 张岳林, 孙军辉, 聂春晖, 陈黎明, 蔡丽霞, 何建娣, 章丽霞, 王伟林, 郑树森. 肝动脉化疗栓塞次数对肝癌根治术后复发的影响[J]. 中国肿瘤临床, 2013, 40(16): 975-978. DOI: 10.3969/j.issn.1000-8179.20121406
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Yuelin ZHANG, Junhui SUN, Chunhui NIE, Liming CHEN, Lixia CAI, Jiandi HE, Lixia ZHANG, WANG Weilin, Shusen ZHENG. Effect of frequency of transcatheter arterial chemoembolization on preventing tumor recurrence after radical resection for hepatocellularcar cinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 40(16): 975-978. DOI: 10.3969/j.issn.1000-8179.20121406
Citation: Yuelin ZHANG, Junhui SUN, Chunhui NIE, Liming CHEN, Lixia CAI, Jiandi HE, Lixia ZHANG, WANG Weilin, Shusen ZHENG. Effect of frequency of transcatheter arterial chemoembolization on preventing tumor recurrence after radical resection for hepatocellularcar cinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 40(16): 975-978. DOI: 10.3969/j.issn.1000-8179.20121406
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肝动脉化疗栓塞次数对肝癌根治术后复发的影响

Effect of frequency of transcatheter arterial chemoembolization on preventing tumor recurrence after radical resection for hepatocellularcar cinoma

    摘要
  • 摘要:
      目的  比较不同次数肝动脉化疗栓塞术（TACE）预防原发性肝癌（HCC）术后复发的作用。
      方法  回顾性收集2008年1月至2009年6月HCC根治术后接受1次和3次预防性TACE的患者45例, 其中接受1次TACE组23例, 接受3次TACE组22例, 两个组均在术后1~2个月给予首次TACE, 此后接受3次TACE组每隔2~4个月重复1次。全部病例在根治术后随访36~40个月, 对比分析两组间的累计复发率。
      结果  HCC根治术后, 接受1次TACE组1、2、3年累计复发率分别为30.43%, 47.83%, 47.83%;接受3次TACE组1、2、3年累计复发率分别为4.55%, 27.27%, 36.36%。统计学分析结果显示接受3次TACE组的1年内复发率明显低于接受1次TACE组（P=0.022）, 而2、3年累积复发率两组间差异无统计学意义（P=0.086、P=0.225）。
      结论  HCC根治术后给予3次预防性TACE能明显降低术后复发高峰期的复发率, 延长肝癌患者术后的无瘤生存时间。

     

    Abstract:
      Objective  To compare the effect of the frequency of transcatheter arterial chemoembolization (TACE) on preventingtumor recurrence after hepatectomy.
      Methods  A total of 45 post-operative patients who had received prophylactic TACE once or thricewere retrospectively examined between January 2008 and June 2009. Of the 45 patients, 23 underwent TACE once, and the others underwentit thrice. TACE was administered to all patients via the hepatic artery one to two months after operation and was repeated everytwo to four months with patients who underwent TACE three times. All cases were followed up for 36 to 40 months after surgery. Therates of cumulative recurrence between the two groups were compared.
      Results  In the group that underwent TACE once, the 1-, 2- and3-year cumulative recurrence rates were 30.43%, 47.83%, and 47.83%, respectively. In the group that underwent TACE thrice, the 1-, 2-and 3-year cumulative recurrence rates were 4.55%, 27.27%, and 36.36%, respectively. Statistical analysis showed that the relapse ratewithin one year was lower in the group that underwent TACE thrice than in the group that underwent TACE only once (P=0.022). However, no significant difference in the cumulative recurrence rate was found between the two groups in two and three years (P=0.086, 0.225).
      Conclusion  Hepatocellular carcinoma patients who undergo preventive TACE three times after hepatectomy exhibit reduced recurrencerates during the peak time of tumor recurrence and extended disease-free survival intervals.

     

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