淋巴细胞绝对计数与多发性骨髓预后的相关性分析

杨瑞芳; 赵志红; 张鹏

doi:10.3969/j.issn.1000-8179.20121876

淋巴细胞绝对计数与多发性骨髓预后的相关性分析

Analysis of prognostic relationship between absolute lymphocyte count and patients with multiple myeloma

摘要

摘要:
目的探讨淋巴细胞绝对计数与多发性骨髓瘤患者疾病进展和预后的相关性。
方法收集102例初发多发性骨髓瘤患者的淋巴细胞绝对计数及各项临床指标，分析淋巴细胞绝对计数与多发性骨髓瘤患者疾病进展和预后的相关性。
结果根据中位淋巴细胞绝对计数分组后得出，组1（淋巴细胞绝对计数＞1.51×10⁹/L）发病年龄、血清乳酸脱氢酶和β2-微球蛋白明显低于组2（淋巴细胞绝对计数 < 1.51×10⁹/L），组1患者中位总生存期大于组2（P < 0.05）。但两组患者性别、白蛋白、D-S分期、ISS分期、分组和疗效差异无统计学意义（P>0.05）。
结论初发时淋巴细胞绝对计数高的患者预后较好，淋巴细胞绝对计数低的患者预后较差。推测淋巴细胞绝对计数可能成为多发性骨髓瘤的独立预后因素之一。

Abstract:
Objective To investigate the relationship between peripheral blood absolute lymphocyte count (ALC) and patients with multiple myeloma (MM).
Methods We obtained clinical features and follow-up data of 102 patients with MM to analyze the prognostic value of peripheral blood ALC.
Results Patients with ALC>1.51×10⁹/L were designated as group 1, whereas patients with ALC < 1.51×10⁹/L were designated as group 2. Group 1 had significantly lower age as well as concentrations of lactate dehydrogenase (LDH) and β2-MG than group 2 (P < 0.05). The overall survival (OS) of group 1 was significantly higher than group 2 (P < 0.05). Sex, ALB, Durie-Salmon stage, isotype, subgroup, and stage according to the International Staging System in group 1 were not significantly different compared with group 2 (P>0.05).
Conclusion Lower ALC is a poor prognosis factor. ALC may be an important prognostic factor of MM.

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