低分化型黏膜内胃癌淋巴结转移的危险因素与腹腔镜手术探讨

吴殿超; 刘丽芳; 霍志斌; 李华; 肖琦海; 穆炳阁; 郭淑敬

doi:10.3969/j.issn.1000-8179.2013.010

低分化型黏膜内胃癌淋巴结转移的危险因素与腹腔镜手术探讨

doi: 10.3969/j.issn.1000-8179.2013.010

吴殿超^①, ,,
刘丽芳^②,
霍志斌^①,
李华^①,
肖琦海^①,
穆炳阁^①,
郭淑敬^①

①.
河北医科大学附属邢台人民医院肿瘤外二科 (河北省邢台市054001）
②.
河北医科大学附属邢台人民医院急救部

基金项目:

邢台市科学基金 20102025-2

详细信息

通讯作者:
吴殿超 wdch1022@163.com

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出版历程
- 收稿日期: 2012-11-15
- 修回日期: 2012-12-21

Risk factors for lymph node metastasis in intramucosal poorly differentiated gastric cancer and reasonable laparoscopic surgery

Dianchao WU^{①
, ,},
Lifang LIU^②,
Zhibin HUO^①,
Hua LI^①,
Qihai XIAO^①,
Bingge MU^①,
Shujing GUO^①

①.
The Second Department of Surgical Oncology, Xingtai People Hospital Affiliated to Hebei Medial University, Xingtai 054001, China
②.
Department of First-aid Center, Xingtai People Hospital Affiliated to Hebei Medial University, Xingtai 054001, China

Funds:

the Scientific Foundation of Xingtai City 20102025-2

More Information

Corresponding author: Dianchao WU; E-mail: wdch1022@163.com

摘要

摘要: 目的探讨低分化型黏膜内胃癌淋巴结转移的危险因素, 从而对低分化型黏膜内胃癌患者, 制定合理腹腔镜术式提供理论依据。方法回顾性分析60例低分化型黏膜内胃癌的临床病理资料, 按照临床病理特征与淋巴结转移的关系进行统计学分析。结果通过多因素分析, 多发肿瘤, 肿瘤大小≥2 cm和淋巴管癌栓阳性对淋巴结转移差异具有统计学意义(P < 0.05)。无危险因素的患者, 淋巴结转移率为0;三个危险因素均有者, 淋巴结转移率高达66.7%。结论多发肿瘤, 肿瘤大小≥2 cm和淋巴管癌栓阳性是低分化型分化型黏膜内胃癌淋巴结转移的独立危险因素。对于无危险因素的患者, 行腹腔镜下胃局部切除术是可行的; 对于具有危险因素的患者, 可以实施腹腔镜下胃癌根治术治疗。
- 早期胃癌 /
- 淋巴结转移 /
- 临床病理特征 /
- 腹腔镜
Abstract: Objective This study aimed to investigate the clinicopathological factors predictive of lymph node metastasis(LNM) in intramucosal poorly differentiated early gastric cancer(EGC), and to expand the possibility of laparoscopic surgery for treating poorly differentiated EGC. Methods Data of 60 patients with intramucosal poorly differentiated EGC and surgically treated in our hospital were collected. The association between the LNM and clinicopathological factors was retrospectively analyzed using univariate and multivariate logistic regression analyses. Results Univariate analysis showed that the tumor size, number of tumors, and lymphatic vessel involvement(LVI) were the significant and independent risk factors for LNM. The LNM rate was 66.7% in patients with the three risk factors. LNM was not found in patients without the three clinicopathological risk factors. Conclusion The tumor size, number of the tumors, and LVI were independently associated with the presence of LNM in intramucosal poorly differentiated EGC. Laparoscopic wedge resection can be sufficient to treat patients without the risk factors. Gastrectomy with lymphadenectomy is inevitable for patients with the risk factors.
- early gastric cancer /
- lymph node metastasis /
- clinicopathologic characteristics /
- laparoscopic surgery

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图 1 D1、D2手术生存率比较

Figure 1. Comparison of survival rates between patients treated with D1 and D2 operation

下载: 全尺寸图片幻灯片

表 1 单变量分析淋巴结转移的影响因素（%，例）

Table 1. Univariate analysis of potential risk factors for lymph node me⁃ tastasis

表 2 多变量分析淋巴结转移的影响因素

Table 2. Multivariate analysis of potential risk factors for lymph node metastasis

表 3 危险因素数目与淋巴结转移率关系

Table 3. Relationship between the number of risk factors and lymph node metastasis

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