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摘要:
目的 探讨早期胃癌淋巴结转移的危险因素。 方法 回顾性分析2005年1月至2010年12月安徽医科大学附属省立医院普外科收治的215例早期胃癌患者的临床病理资料, 并研究早期胃癌淋巴结转移与临床病理因素的关系。 结果 215例患者中淋巴结转移者36例, 单因素分析显示: 肿瘤最大直径(P=0.022)、浸润深度(P=0.003)、Hp感染情况(P=0.004)均与早期胃癌淋巴结转移有关。Logistic多因素回归分析显示: 肿瘤的浸润深度与早期胃癌淋巴结转移有关(P=0.002)。 结论 肿瘤的浸润深度是影响早期胃癌淋巴结转移的独立危险因素。 Abstract:Objective This study was designed to investigate the risk factors for lymph node metastasis in early gastric cancer. Methods We retrospectively analyzed the clinicopathological data of 215 patients with early gastric cancer treated at the Anhui Province Hospital from January 2005 to December 2010.The relationship between lymph node metastasis and cliniopathological factors was evaluated by univariate and multivariable logistic regression analyses. Results Univariate analysis showed that tumor size(P=0.001), depth of invasion(P=0.000), and Helicobacter pylori infection(P=0.000) were associated with lymph node metastasis.Multivariable logistic regression analysis revealed that the depth of invasion was considered a significant risk factor(P < 0.05). Conclusion The depth of invasion is the risk factor for lymph node metastasis in early gastric cancer. -
Key words:
- early gastric cancer /
- lymph node metastasis /
- risk factors
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表 1 215例早期胃癌淋巴结转移的危险因素的单因素分析结果
例 Table 1. Univariate analysis results of the risk factors for lymph node metastasis in 215 patients with early gastric cancer
表 2 早期胃癌淋巴结转移的多因素Logistic分析结果
Table 2. Multivariate logistic analysis results for lymph node metastasis in early gastric cancer
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[1] 李延青. 胃癌的早期诊断[J]. 中华消化杂志, 2011, 31(8): 573-574. doi: 10.3760/cma.j.issn.0254-1432.2011.08.020 [2] 任丽华. 临床早期胃癌32例的内镜诊断及临床分析[J]. 临床和实验医学杂志, 2012, 11(14): 1138-1139. doi: 10.3969/j.issn.1671-4695.2012.14.027 [3] Tae HL, Joo YC, Young WC, et al. Appropriate indications for endoscopic submucosal dissection of early gastric cancer according totumor size and histologic type[J]. Gastrointestinal Endoscopy, 2010, 71(6): 920-926. doi: 10.1016/j.gie.2009.12.005 [4] Sung YK, Yun WK, Min BH, et al. Factors related to lymph nodemetastasis and the feasibility of endoscopic mucosal resection fortreating early gastric cancer[J]. Gastrointestinal Endoscopy, 2010, 71: AB106. [5] Ben EH, Joost AP, Bin KK, et al. Lymph node metastasis in intermediate-risk penile squamous cell cancer: a two-centre experience[J]. Euro Urol, 2010, 57(4): 688-692. doi: 10.1016/j.eururo.2009.07.004 [6] 秦新裕. 不断规范和提高我国胃癌外科治疗水平[J]. 中华普外科手术学杂志(电子版), 2010, 4(2): 1-3. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHPW201002002.htm [7] Ji YA, Hwoon YJ, Kee DC, et al. Endoscopic and oncologic outcomes after endoscopic resection for early gastric cancer: 1370 cases of absolute and extended indications[J]. Gastrointestinal Endoscopy, 2011, 74(3): 485-493. doi: 10.1016/j.gie.2011.04.038 [8] 方仪, 郑朝旭, 冯强, 等. 早期胃癌的临床诊疗特点和预后分析[J]. 中国肿瘤临床, 2009, 36(8): 199-201. doi: 10.3969/j.issn.1000-8179.2009.08.006 [9] Valeska PL, Isabelle JL, Markênia KS, et al. Prevalence of Helicobacter pylori genotypes(vacA, cagA, cagE and virB11)in gastriccancer in Brazilian's patients: An association with histopathologicalparameters[J]. Cancer Epidemiol, 2011, 35(5): 32-37. doi: 10.1016/j.canep.2011.02.017 [10] 周俊伟. 幽门螺杆菌感染与胃癌的相关性[J]. 中华医院感染学杂志, 2012, 22(21): 4799-4800. https://www.cnki.com.cn/Article/CJFDTOTAL-ZHYY201407058.htm [11] 施新岗, 李兆申. 内镜黏膜下剥离术治疗早期胃癌进展[J]. 中华消化内镜杂志, 2008, 25(1): 52-54. doi: 10.3760/cma.j.issn.1007-5232.2008.01.024 [12] 王鑫, 金晶, 李晔雄, 等. 局部晚期胃癌术后预后因素分析及对术后辅助治疗意义探讨[J]. 中华放射肿瘤学杂志, 2011, 20(4): 306-311. doi: 10.3760/cma.j.issn.1004-4221.2011.04.013 [13] Nobutsugu A, Hirohisa T, Atsuko O, et al. Long-term outcomes ofcombination of endoscopic submucosal dissection and laparoscopiclymph node dissection without gastrectomy for early gastric cancerpatients who have a potential risk of lymph node metastasis[J]. Gastrointestinal Endoscopy, 2011, 74(4): 792-797. doi: 10.1016/j.gie.2011.06.006 [14] Consideration of the role of radiotherapy for abdominal lymphnode metastases in patients with recurrent gastric cancer original research article international J of Radi Oncol Biol Phys, 77, 2010(2): 384-391. [15] Yu JW, Wu JG, Yusuke T, et al. Study on lymph node metastasiscorrelated to lymphangiogenesis, lymphatic vessel invasion, andlymph node micrometastasis in gastric cancer[J]. J of Surg Res, 2011, 168(2): 188-196. doi: 10.1016/j.jss.2009.10.030
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