MicroRNAs对肿瘤相关巨噬细胞的趋化及表型的影响

彭妍; 李国利; 张艳青

doi:10.3969/j.issn.1000-8179.2013.02.015

MicroRNAs对肿瘤相关巨噬细胞的趋化及表型的影响

doi: 10.3969/j.issn.1000-8179.2013.02.015

扬州大学医学院病理学教研室（江苏省扬州市225000）

基金项目:

江苏省高校自然科学研究项目 12KJD320007

详细信息

通讯作者:
李国利 Lgl01012000@yahoo.com.cn

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出版历程
- 收稿日期: 2012-08-27
- 修回日期: 2012-12-11

Effects of microRNAs on the chemotaxis and polarization of tumor-associated macrophage

Department of Pathology, Yangzhou University Medical School, Yangzhou 225000 China

Funds:

Natural Science Research Project of Jiangsu Provincial Colleges and Universities 12KJD320007

More Information

Corresponding author: Guoli LI; E-mail: Lgl01012000@yahoo.com.cn

摘要

摘要: 单核-巨噬细胞是机体固有免疫反应的重要组成部分, 在肿瘤间质中浸润有大量巨噬细胞, 被称为肿瘤相关巨噬细胞(tumor-associated macrophage, TAM)。MicroRNAs(miRNAs, miRs)是一类由内源基因编码, 长度约为22个核苷酸的非编码单链RNA分子。miRNA与目标基因3'不翻译区(3'-UTR)结合, 抑制靶蛋白的表达, 在转录后水平对目标基因的表达水平进行调控。miRNAs可通过调控趋化因子及炎症因子影响巨噬细胞的趋化和分化。本文将近几年关于miRNAs对TAM的趋化及表型影响的研究结果进行综述。
- MicroRNAs /
- 肿瘤相关巨噬细胞 /
- 趋化因子
Abstract: The mononuclear macrophage is an important part of the innate immune response of the human body.Macrophages accumulate in tumor tissues, where they become tumor-associated macrophages.MiRNAs are small(22 nt) noncoding RNA molecules that post-transcriptionally regulate gene expression by targeting the 3' untranslated region(3'-UTR) of specific messenger RNAs(mRNAs), resulting in mRNA degradation or translation repression.Many studies have found that miRNAs affect macrophage chemotaxis and differentiation through the regulation of chemokines and inflammatory cytokines.This review summarizes the advances in the research on the effects of microRNAs on the chemotaxis and polarization of tumor-associated macrophages.
- microRNAs /
- tumor-associated macrophage /
- chemotactic factor

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参考文献(29)

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