金夏祥, 诸炯, 王爱忠, 俞国冰, 邬丹钰, 唐晓兰. E-cadherinP120ctn在乳腺癌中的表达及意义[J]. 中国肿瘤临床, 2013, 40(3): 144-147. DOI: 10.3969/j.issn.1000-8179.2013.03.006
引用本文: 金夏祥, 诸炯, 王爱忠, 俞国冰, 邬丹钰, 唐晓兰. E-cadherinP120ctn在乳腺癌中的表达及意义[J]. 中国肿瘤临床, 2013, 40(3): 144-147. DOI: 10.3969/j.issn.1000-8179.2013.03.006
shu
Xia-xiang JIN, Jiong ZHU, Ai-zhong WANG, Guo-bing YU, Dan-yu WU, Xiao-lan TANG. Expression and significance of E-cadherin and P120 catenin in breast cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 40(3): 144-147. DOI: 10.3969/j.issn.1000-8179.2013.03.006
Citation: Xia-xiang JIN, Jiong ZHU, Ai-zhong WANG, Guo-bing YU, Dan-yu WU, Xiao-lan TANG. Expression and significance of E-cadherin and P120 catenin in breast cancer[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 40(3): 144-147. DOI: 10.3969/j.issn.1000-8179.2013.03.006
shu

E-cadherinP120ctn在乳腺癌中的表达及意义

Expression and significance of E-cadherin and P120 catenin in breast cancer

    摘要
  • 摘要:
      目的  探讨E-钙黏蛋白(E-cadherin, E-cad)、P120连环蛋白(P120ctn)在乳腺浸润性导管癌(IDC)和浸润性小叶癌(ILC)中的表达及其鉴别诊断意义。
      方法  收集解放军第113医院2007年12月至2012年5月间有完整随访资料的浸润性导管癌60例、浸润性小叶癌48例及混合性癌20例。采用免疫组织化学S-P法检测E-cad及P120的表达。
      结果  E-cad在IDC和ILC中的阳性率分别为85%(51/60)和0, 其差异有统计学意义(P < 0.01);P120在IDC中阳性率为100%, 且均为细胞膜着色, 而在ILC中阳性率亦为100%, 但均为胞浆着色。E-cad和P120联合使用将20例混合癌确诊为IDC 16例及ILC 4例。IDC中E-cad的表达水平与肿瘤分期无关, 与淋巴结转移有关(P < 0.05)。
      结论  E-cad和P120联合使用可以鉴别光镜下易混淆的IDC和ILC, 使组织分型更准确, 建议应用于乳腺癌的常规免疫组织化学检测。E-cad的表达水平与淋巴结转移有关。

     

    Abstract:
      Objective  To explore the expression of E-cadherin and p120 catenin in invasive ductal carcinoma(IDC) and invasive lobular carcinoma(ILC) and their significance for differential diagnosis.
      Methods  A total of 60 cases with IDCs, 48 invasive lobular carcinomas, and 20 invasive carcinomas with mixed ductal and lobular features were collected from No.113 Hospital of People's Liberation Army.An immunohistochemical study for E-cadherin and P120 catenin was performed using a streptavidin–peroxidase method.
      Results  The positivity rates for E-cadherin in IDC and classic ILC were 85%(51/60) and 0%, respectively(P < 0.01).The positivity rates for p120 catenin were 100% in both IDC(membranous staining) and classic ILC(cytoplasmic staining).E-cadherin and p120 catenin were used to classify 20 mixed carcinomas into 16 IDCs and 4 ILCs.No significant difference was found in E-cadherin expression level in different histological types of IDC was indicated.However, E-cadherin expression was coincided with lymph node metastasis(P < 0.05).
      Conclusion  E-cadherin and p120 catenin are useful immunomarkers to distinguish IDCs from ILCs and thus can be used in routine immunohis to chemistry in breast cancer.The E-cad expression level coincides with lymph node metastasis in IDC.

     

    • HTML全文
    • 参考文献(10)
    • 相关文章
    • 施引文献
  • 资源附件(0)

/

返回文章
返回