张炜炜, 阿布力克木·毛拉尤甫, 阿仙姑·哈斯木, 郑超, 玛依努尔·艾力. 幽门螺旋杆菌感染与胃癌侵袭转移及血浆核黄素水平的关系[J]. 中国肿瘤临床, 2013, 40(3): 153-156. DOI: 10.3969/j.issn.1000-8179.2013.03.008
引用本文: 张炜炜, 阿布力克木·毛拉尤甫, 阿仙姑·哈斯木, 郑超, 玛依努尔·艾力. 幽门螺旋杆菌感染与胃癌侵袭转移及血浆核黄素水平的关系[J]. 中国肿瘤临床, 2013, 40(3): 153-156. DOI: 10.3969/j.issn.1000-8179.2013.03.008
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Wei-wei ZHANG, Abulikemu·MAOLAYOUFU, Axiangu·HASIMU, Chao ZHENG, Mayinuer·AILI. Relationship among helicobacter pylori infection, invasion and metastasis of gastric carcinoma, and plasma riboflavin level[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 40(3): 153-156. DOI: 10.3969/j.issn.1000-8179.2013.03.008
Citation: Wei-wei ZHANG, Abulikemu·MAOLAYOUFU, Axiangu·HASIMU, Chao ZHENG, Mayinuer·AILI. Relationship among helicobacter pylori infection, invasion and metastasis of gastric carcinoma, and plasma riboflavin level[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 40(3): 153-156. DOI: 10.3969/j.issn.1000-8179.2013.03.008
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幽门螺旋杆菌感染与胃癌侵袭转移及血浆核黄素水平的关系

Relationship among helicobacter pylori infection, invasion and metastasis of gastric carcinoma, and plasma riboflavin level

    摘要
  • 摘要:
      目的  探讨幽门螺旋杆菌(Helicobacter pylori, Hp)感染与胃癌患者侵袭转移及血浆核黄素水平的关系。
      方法  采用Warthin-starry组织染色法、快速尿素酶试验及14C-UBT检测Hp感染。采用高效液相色谱法检测胃癌患者的血浆核黄素水平。
      结果  Hp感染胃癌组浆膜侵袭率与淋巴结转移率分别为62.5%和75%, 高于无Hp感染胃癌组14.3%和42.9%(P < 0.001, P=0.001 1)。胃癌无浆膜侵袭组和无淋巴结转移组血浆核黄素水平分别为1.870 6 ng/mL和2.381 1 ng/mL, 高于浆膜侵袭组、淋巴结转移组(分别为0.733 1 ng/mL和0.795 0 ng/mL), 两组血浆核黄素水平差异有统计学意义(P=0.013, P=0.046)。胃癌无HP感染组的血浆核黄素水平(1.667 4±0.370 09)ng/mL高于Hp感染组(1.220 7±0.177 27)ng/mL, 血浆核黄素水平差异有统计学意义(P=0.043)。
      结论  Hp感染可能会影响胃癌患者预后和血浆核黄素水平。

     

    Abstract:
      Objective  This study aims to explore the relationship among Helicobacter pylori infection, invasion and metastasis of gastric carcinoma, and plasma riboflavin level.
      Methods  The Warthin-Starry method, rapid urease test, and 14C-urea breath test were used to detect H.pylori infection.High-performance liquid chromatography was used to detect the level of riboflavin in gastric carcinoma plasma.
      Results  The incidence of serosal invasion and lymph node metastasis in gastric carcinoma patients with H.pylori infection(62.5% and 75%, respectively) was significantly higher than that in gastric carcinoma patients without infection(7.7% and 42.8%, respectively; P < 0.001, P=0.001 1).The levels of plasma riboflavin in gastric cancer patients without serosal invasion and without lymph node metastasis were 1.8706 and 2.381 1 ng/mL, respectively, which are higher than those in gastric cancer patients with serosal invasion and lymph node metastasis(0.733 1 and 0.795 0 ng/mL, respectively).Statistically significant differences in plasma riboflavin level were found between the two groups(P=0.013, P=0.046).The level of plasma riboflavin in gastric cancer patients without H.pylori infection(1.667 4 ng/mL± 0.370 09 ng/mL) was higher than that in gastric cancer patients with H.pylori infection(1.220 7 ng/mL ± 0.177 27 ng/mL)(P=0.043).
      Conclusion  H.pylori infection may affect the prognosis of patients with gastric cancer and plasma riboflavin level.

     

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