Abstract:
Objective This study aims to explore the relationship among Helicobacter pylori infection, invasion and metastasis of gastric carcinoma, and plasma riboflavin level.
Methods The Warthin-Starry method, rapid urease test, and 14C-urea breath test were used to detect H.pylori infection.High-performance liquid chromatography was used to detect the level of riboflavin in gastric carcinoma plasma.
Results The incidence of serosal invasion and lymph node metastasis in gastric carcinoma patients with H.pylori infection(62.5% and 75%, respectively) was significantly higher than that in gastric carcinoma patients without infection(7.7% and 42.8%, respectively; P < 0.001, P=0.001 1).The levels of plasma riboflavin in gastric cancer patients without serosal invasion and without lymph node metastasis were 1.8706 and 2.381 1 ng/mL, respectively, which are higher than those in gastric cancer patients with serosal invasion and lymph node metastasis(0.733 1 and 0.795 0 ng/mL, respectively).Statistically significant differences in plasma riboflavin level were found between the two groups(P=0.013, P=0.046).The level of plasma riboflavin in gastric cancer patients without H.pylori infection(1.667 4 ng/mL± 0.370 09 ng/mL) was higher than that in gastric cancer patients with H.pylori infection(1.220 7 ng/mL ± 0.177 27 ng/mL)(P=0.043).
Conclusion H.pylori infection may affect the prognosis of patients with gastric cancer and plasma riboflavin level.