经皮肝动脉栓塞化疗联合洛铂热灌注化疗治疗不能手术切除的肝细胞癌的近期疗效观察

张鹏; 李晓冰; 任虎虎; 卫飞鹏; 刘晓宇; 宫卫东

doi:10.3969/j.issn.1000-8179.2013.05.010

经皮肝动脉栓塞化疗联合洛铂热灌注化疗治疗不能手术切除的肝细胞癌的近期疗效观察

Early-stage therapeutic effects of thermochemotherapy and embolization via hepatic artery intervention in the treatment of unresectable primary liver cancer

摘要

摘要:
目的探讨经皮肝动脉栓塞化疗联合洛铂热灌注化疗在治疗肝细胞癌中的近期疗效。
方法对20例不能手术切除的肝细胞癌患者进行肝动脉热灌注化疗栓塞术, 先采用洛铂联合盐酸表柔比星、丝裂霉素行热灌注化疗, 然后行常规肝动脉栓塞化疗, 间隔40~50天再次治疗, 2次治疗后评价近期治疗效果及不良反应。
结果 20例患者显效4例(20.0%), 有效7例(35.0%), 稳定7例(35.0%), 进展2例(10.0%)。总有效率为55.0%。AFP下降 > 50%者8例, 其中2例恢复正常。
结论肝动脉热灌注洛铂为主的联合化疗方案+栓塞术治疗肝细胞癌安全有效, 其远期疗效有待进一步观察。

Abstract:
Objective This study aims to explore the early-stage therapeutic effects of lobaplatin-based thermochemotherapy and embolization via hepatic artery intervention in the treatment of unresectable primary liver cancer.
Methods Thermochemotherapy and embolization were used to treat 20 unresectable primary liver cancer patients.Epirubicin, mitomycin, and lobaplatin were used for thermochemotherapy.The process was repeated once after 40 d to 50 d.After the two treatment periods, the early effects and side effects were observed.
Results Among the 20 cases, 4(20.0%) received excellent efficacy, 7(35.0%) received good effect, 7(35.0%) demonstrated stabilization, and 2 showed advancement, with a total effective rate of 55.0%.The content of alpha fetoprotein dropped by over 50% in 8 cases, among which 2 returned to normal.
Conclusion The use of thermochemotherapy and embolization via hepatic artery intervention is an effective and safe treatment for primary liver cancer.However, the long-term effects of this treatment need further observation.

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