Abstract: NK/T-cell lymphoma has a poor prognosis because of the invasiveness of this disease.No effective treatments exist for this condition.Aside from causing histologic and EBV-related changes, the disease also causes chromosome abnormality, gene mutation, and abnormality in the signal pathway and protein expression.Thus, many domestic and international scholars have conducted sustainable in-depth studies on the pathogenesis of the tumor.This paper summarizes the research progress on the pathogenesis of NK/T-cell lymphoma.