汪娇, 戴东, 宋秀宇, 朱研佳, 张莹, 徐文贵. 18F-FDGPET/CT显像在评估胆囊癌预后中的价值[J]. 中国肿瘤临床, 2013, 40(7): 410-413. DOI: 10.3969/j.issn.1000-8179.2013.07.010
引用本文: 汪娇, 戴东, 宋秀宇, 朱研佳, 张莹, 徐文贵. 18F-FDGPET/CT显像在评估胆囊癌预后中的价值[J]. 中国肿瘤临床, 2013, 40(7): 410-413. DOI: 10.3969/j.issn.1000-8179.2013.07.010
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Jiao WANG, Dong DAI, Xiuyu SONG, Yanjia ZHU, Ying ZHANG, Wengui XU. Role of 18F-FDG PET/CT imaging in the prognosis of gallbladder carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 40(7): 410-413. DOI: 10.3969/j.issn.1000-8179.2013.07.010
Citation: Jiao WANG, Dong DAI, Xiuyu SONG, Yanjia ZHU, Ying ZHANG, Wengui XU. Role of 18F-FDG PET/CT imaging in the prognosis of gallbladder carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 40(7): 410-413. DOI: 10.3969/j.issn.1000-8179.2013.07.010
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18F-FDGPET/CT显像在评估胆囊癌预后中的价值

Role of 18F-FDG PET/CT imaging in the prognosis of gallbladder carcinoma

    摘要
  • 摘要:
      目的  探讨治疗前18F-FDG PET/CT显像在胆囊癌患者预后中的作用。
      方法  回顾2005年4月至2012年11月临床可疑胆囊癌并行18F-FDG PET/CT检查的95例患者, 分析PET/CT显像及其他相关因素与患者预后之间的关系, 研究PET/CT显像在评估胆囊癌预后中的价值。
      结果  Kaplan-Meier单因素分析显示A组(SUVmax值≤8.5)与B组(SUVmax值> 8.5)患者的中位生存时间(266, 166天)差异有统计学意义(P < 0.05);PET/CT分期不同的患者之间的生存时间有显著性差异(P < 0.05)。Cox多因素分析显示SUVmax值、术前血清CA19-9水平和治疗情况是本组患者生存预后的独立影响因素。
      结论  PET/CT分期及肿瘤原发部位的SUVmax值在评估胆囊癌患者预后方面具有一定的临床价值, 能够指导临床尽早制定个体化治疗方案, 提高胆囊癌的早期诊断率, 可望延长患者生存期。

     

    Abstract:
      Objective  This study aimed to evaluate the role of 18F-FDG PET/CT imaging in predicting the prognosis of patients with gallbladder carcinoma.
      Methods  A total of 95 patients who were clinically suspected with gallbladder carcinoma from April 2005 to November 2012 were examined by 18F-FDG PET/CT.All cases were confirmed for gallbladder carcinoma; 68 cases were found to be pathological, and 27 were found to be long-term clinical follow-up cases.The relationship of PET/CT imaging date and other factors with the survival of the 95 patients with gallbladder carcinoma were retrospectively analyzed to evaluate the role of PET/CT imaging in the prognosis of patients with gallbladder carcinoma.
      Results  A total of 51 patients died and 44 patients survived out of the 95 patients with gallbladder carcinoma.Kaplan-Meier analysis showed that the survival time of patients in group A(SUVmax≤8.5) and group B(SUVmax > 8.5) was statistically different(266, 166) at P < 0.05.The survival time of patients belonging to different PET/CT staging was also statistically different at P < 0.05.Cox multi-factor analysis indicated(maximum standardized uptake values, SUVmax) that the preoperative serum(CA19-9) level and treatment methods were all independent risk factors that prevented the long-term survival of the patients.
      Conclusion  PET/CT staging and SUVmax of the primary tumor before treatment are important in estimating the prognosis of patients with gallbladder carcinoma.PET/CT staging and SUVmax can be utilized to set immediate individualized treatment, improve the curative effect, and extend the lifespan of patients with gallbladder carcinoma.

     

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