Abstract:
Objective This work aimed to investigate the clinicopathologic characteristics of non-functioning islet cell tumor(NFICT) and to analyze the homologous prognostic factors
Methods Clinical data of 70 surgically treated patients with pathologically confirmed NFICT over the past 10 years were analyzed.The patients were admitted in Tianjin Medical University Tianjin Cancer Hospital.The related factors, such as patient age and gender, pre-operative abdominal and/or back pain, CA19-9 level, tumor size, pathologic type, surgical procedure, tumor-node-metastasis(TNM) stage lymphatic metastasis and adjuvant therapy, were analyzed.
Results Of the 70 patients, 39 were diagnosed with non-functioning islet cell carcinomas and 31 with benign islet cell tumors.In the 70 cases, the median survival time was 88 months, and the 1-, 3-, and 5-year overall survival times were 82.4%, 68.8%, and 52.8%, respectively.Univariate analysis showed that tumor size, pathologic type, surgical procedure, TNM stage, and lymphatic metastasis were associated with the prognosis(P > 0.05).Multivariate analysis showed that tumor size(P=0.001), surgical procedure(P=0.000), and lymphatic metastasis(P=0.002) were predictors of prognosis.
Conclusion Small tumor size(P > 10 cm), absence of lymphatic metastasis, and radical resection improve the survival of NFICT patients.