Abstract:
Objective The present study aimed to assess serum macrophage migration inhibitory factor (MIF), interleukin (IL) -17, and IL-10 in hepatocellular carcinoma (HCC) and discuss their clinical importance.
Methods We chose 48 cases of HCC and 36 cases of liver cirrhosis (LC) as the experimental groups.We also selected 24 normal subjects (NS) as the control group.Enzyme-linked immunosorbent assay was performed to determine the concentrations of MIF, IL-17, and IL-10 in the peripheral serum of the three groups.
Results MIF and IL-17 concentrations in HCC and LC groups were higher.By contrast, IL-10 concentration was lower in the experimental groups than in the control group.A significant difference was observed between the experimental group and the control group (P < 0.05).MIF and IL-17 concentrations in the HCC group were not significantly different from those in the LC group (P > 0.05).
Conclusion MIF, IL-17, and IL-10 concentrations were correlated with HCC and LC, indicating their clinical importance.