Abstract:
Objective We aimed to compare the efficacy and side effects of three-dimensional conformal radiotherapy (3DCRT) and conventional radiotherapy for treating postoperative gliomas.
Methods We retrospectively analyzed the data of 83 cases of postoperative gliomas that received radiotherapy from January 2001 to December 2010 in our hospital.The Kaplan–Meier method was used to calculate the tumor-free survival and overall survival (OS) rate.The log-rank test was conducted to determine significance.The chi-squared test was used to compare the differences among the clinical characteristics and toxicity.
Results The OS and progression-free survival (PFS) rates for 3 years of all 83 cases were 76.3% and 72.2%, respectively.The OS and PFS for 3 years were 82.5% and 78.2% for 3DCRT, as well as 66.9% and 64.1% for conventional radiotherapy.Stratified analysis showed that 3DCRT mainly improved the OS and PFS rates of residual glioma and higher-grade (pathological grades Ⅲ~Ⅳ) gliomas.
Conclusion Higher OS and PFS rates, lower incidence of herniation, and more delayed radiation-induced brain injury were achieved with 3DCRT than with conventional radiotherapy.